Engineering von intrazellulären Modulatoren


The engineering of affinity reagents has become a standard technology in modern drug development efforts. High-throughput screening of recombinant protein libraries has yielded numerous affinity reagents that are used in diagnostic or therapeutic applications. In our approach, we engineer intracellular affinity reagents by enhancing pre-existing intermolecular contacts to target functional epitopes in proteins. The designed affinity reagents allow a fast and specific interrogation of druggable sites in therapeutic relevant proteins.

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Correspondence to Andreas Ernst.

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Svenja Wiechmann 20072013 Biologiestudium an der TU Darmstadt. Seit 2013 Doktorandin im Institut für Biochemie II, Goethe Universität Frankfurt a. M.

Andreas Ernst 19932000 Chemiestudium an der TU Darmstadt. 20002006 Promotion an der Universität Zürich, Schweiz, im Labor von Prof. Dr. Andreas Plückthun. 20072008 Postdoc in San Francisco, CA, USA, im Department Proteinengineering bei Genentech in der Arbeitsgruppe von Dr. S. Sidhu. 2008 Umzug mit Dr. S. Sidhu an die Universität Toronto, Kanada, an das Centre for Cellular and Biomolecular Research. Seit 2013 Gruppenleiter im Institut für Biochemie II, Goethe Universität Frankfurt a. M. und seit 2015 in Nebentätigkeit als Gruppenleiter am Fraunhofer-Institut für Molekular biologie und Angewandte Ökologie, Projektgruppe Translationale Medizin und Pharmakologie, Frankfurt a. M.

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Wiechmann, S., Ernst, A. Engineering von intrazellulären Modulatoren. Biospektrum 23, 769–771 (2017).

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