Abstract
Lipoproteins (Lpp) of Gram-positive bacteria play a crucial role in immune modulation. The degree of lipid acylation determines whether the TLR2/TLR1 or the TLR2/TLR6 signalling pathway is induced in the infected host. Both pathways differ significantly in the extent of innate immune activation. Commensal bacteria on our skin signal via the TLR2/TLR1 pathway thus inducing only a mild immune response while non-commensal bacteria signal via TLR2/TLR6 pathway thereby inducing a fulminant immune response. Consequently, the structure of the lipid residue in Lpp decides over immune tolerance or intolerance.
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Minh-Thu Nguyen B. Sc. an der Vietnam National University (Hanoi) am College of Natural Sciences. M. Sc. an der Sungkyunkwan University, Südkorea. 2010 mit Stipendium der Regierung Vietnam an die Universität Tübingen (seit Juli 2014 DFG-finanziert). Seit 2016 Postdoc der AG Mikrobielle Genetik an der Universität Tübingen.
Friedrich Götz Biologie- und Chemiestudium an der LMU München; 1978 Promotion bei Prof. Dr. K.-H. Schleifer. 1980–1981 EMBO Long-Term Fellowship für Postdoc-Aufenthalt an der Universität Uppsala, Schweden.1985 Habilitation an der TU München. Seit 1987 Lehrstuhl Mikrobielle Genetik an der Universität Tübingen. Seit 2015 Seniorpro fessor an der Universität Tübingen.
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Nguyen, M.T., Götz, F. Wie bakterielle Moleküle unser Immunsystem manipulieren. Biospektrum 23, 759–761 (2017). https://doi.org/10.1007/s12268-017-0867-4
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DOI: https://doi.org/10.1007/s12268-017-0867-4