Skip to main content
SpringerLink
Log in

Intrazellulär gut vernetzt - das Proteom der chlamydialen Inklusion

  • Wissenschaft
  • Pathogen-Wirt-Interaktionen
  • Published:
BIOspektrum Aims and scope

Abstract

Chlamydia trachomatis is an important human pathogen with over 130 million new infections per year, world-wide. This obligate intracellular bacterium grows inside a membrane-bound compartment - the inclusion. Recently, using a global approach we were able to comprehensively describe the interactions of the bacterium with cellular proteins. These data indicate the inclusion is an intracellular trafficking hub embedded into the cellular vesicular trafficking pathways.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Newman L, Rowley J, Vander Hoorn S et al. (2015) Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting. PLoS One 10:e0143304

    Google Scholar 

  2. Malhotra M, Sood S, Mukherjee A et al. (2013) Genital Chlamydia trachomatis: an update. Indian J Med Res 138:303–316

    PubMed  PubMed Central  Google Scholar 

  3. Batteiger BE, Tu W, Ofner S et al. (2010) Repeated Chlamydia trachomatis genital infections in adolescent women. J Infect Dis 201:42–51

    Article  PubMed  PubMed Central  Google Scholar 

  4. Moulder JW (1991) Interaction of chlamydiae and host cells in vitro. Microbiol Rev 55:143–190

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Mehlitz A, Rudel T (2013) Modulation of host signaling and cellular responses by Chlamydia. Cell Commun Signal 11:90

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Elwell C, Mirrashidi K, Engel J (2016) Chlamydia cell biology and pathogenesis. Nat Rev Microbiol 14:385–400

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Sinai AP, Joiner KA (1997) Safe haven: the cell biology of nonfusogenic pathogen vacuoles. Annu Rev Microbiol 51:415–462

    Article  CAS  PubMed  Google Scholar 

  8. Rzomp KA, Scholtes LD, Briggs BJ et al. (2003) Rab GTPases are recruited to chlamydial inclusions in both a species- dependent and species-independent manner. Infect Immun 71:5855–5870

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Herweg JA, Hansmeier N, Otto A et al. (2015) Purification and proteomics of pathogen-modified vacuoles and membranes. Front Cell Infect Microbiol 5:48

    Article  PubMed  PubMed Central  Google Scholar 

  10. Aeberhard L, Banhart S, Fischer M et al. (2015) The proteome of the isolated Chlamydia trachomatis containing vacuole reveals a complex trafficking platform enriched for retromer components. PLoS Pathog 11:e1004883

    Article  Google Scholar 

  11. Haft CR, de la Luz Sierra M, Bafford R et al. (2000) Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell 11:4105–4116

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fachgebiet 19 „Sexuell übertragbare bakterielle Krankheitserreger“, Robert Koch-Institut, Nordufer 20, D-13353, Berlin, Deutschland

    Sebastian Banhart & Dagmar Heuer

Authors
  1. Sebastian Banhart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dagmar Heuer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dagmar Heuer.

Additional information

Sebastian Banhart 2000–2007 Biologiestudium an den Universitäten Stuttgart und Hamburg. 2011 Dissertation am Max-Planck-Institut für Infektionsbiologie, Berlin (Prof. Dr. T. F. Meyer). Seit 2011 wissenschaftlicher Mitarbeiter am Robert Koch-Institut, Berlin.

Dagmar Heuer 1994–1999 Humanbiologiestudium an der Universität Marburg. 2004 Dissertation am Max-Planck-Institut für Infektionsbiologie, Berlin und an der Universität Marburg (Prof. Dr. T. F. Meyer und Prof. Dr. H.-D. Klenk). 2004–2011 wissenschaftliche Mitarbeiterin und Teamleiterin am Max-Planck-Institut für Infektionsbiologie, Berlin. 2011–2017 Nachwuchsgruppen- und seit 2017 Fachgebietsleiterin am Robert Koch-Institut, Berlin.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Banhart, S., Heuer, D. Intrazellulär gut vernetzt - das Proteom der chlamydialen Inklusion. Biospektrum 23, 756–758 (2017). https://doi.org/10.1007/s12268-017-0866-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-017-0866-5

Search

Navigation