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Redoxbiochemie des genetischen Codes

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  • Molekulare Evolution
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Abstract

Recent research on the quantum chemistry of the amino acids and on the temporal order of their ancient introduction into the genetic code has yielded the surprising finding that the amino acids have become system-atically softer (i. a. meaning more redox reactive) during evolution. This trend is recapitulated by recent innovations in organelle genetic codes found in present-day animals. Thus, aspects of chemical reactivity rather than three-dimensional structure optimization governed the finalization of the modern genetic code.

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Literatur

  1. Koonin EV, Novozhilov AS (2009) Origin and evolution of the genetic code: the universal enigma. IUBMB Life 61:99–111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Longo LM, Blaber M (2012) Protein design at the interface of the pre-biotic and biotic worlds. Arch Biochem Biophys 526:16–21

    Article  CAS  PubMed  Google Scholar 

  3. Trifonov EN (2009) The origin of the genetic code and of the earliest oligopeptides. Res Microbiol 160:481–486

    Article  CAS  PubMed  Google Scholar 

  4. Granold M (2015) Die Bedeutung von molekularem Sauerstoff für die Evolution des genetischen Codes. Dissertation, Universität Mainz

    Google Scholar 

  5. Bender A, Hajieva P, Moosmann B (2008) Adaptive antioxidant methionine accumulation in respiratory chain complexes explains the use of a deviant genetic code in mitochondria. Proc Natl Acad Sci USA 105:16496–16501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Schindeldecker M, Moosmann B (2015) Protein-borne methionine residues as structural antioxidants in mitochondria. Amino Acids 47:1421–1432

    Article  CAS  PubMed  Google Scholar 

  7. Levine RL, Mosoni L, Berlett BS et al. (1996) Methionine residues as endogenous antioxidants in proteins. Proc Natl Acad Sci USA 93:15036–15040

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Gray HB, Winkler JR (2015) Hole hopping through tyrosine/tryptophan chains protects proteins from oxidative damage. Proc Natl Acad Sci USA 112:10920–10925

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hajieva P, Bayatti N, Granold M et al. (2015) Membrane protein oxidation determines neuronal degeneration. J Neurochem 133:352–367

    Article  CAS  PubMed  Google Scholar 

  10. Lyons TW, Reinhard CT, Planavsky NJ (2014) The rise of oxygen in Earth’s early ocean and atmosphere. Nature 506:307–315

    Article  CAS  PubMed  Google Scholar 

  11. Yang XL, Otero FJ, Skene RJ et al. (2003) Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains. Proc Natl Acad Sci USA 100:15376–15380

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Jones TE, Ribas de Pouplana L, Alexander RW (2013) Evidence for late resolution of the AUX codon box in evolution. J Biol Chem 288:19625–19632

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Evolutionäre Biochemie und Redoxmedizin, Institut für Pathobiochemie, Universitätsmedizin der Universität Mainz, Duesbergweg 6, D-55128, Mainz, Deutschland

    Bernd Moosmann

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  1. Bernd Moosmann
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Correspondence to Bernd Moosmann.

Additional information

Bernd Moosmann Jahrgang 1973. 1992–1998 Studium an der LMU München und der FU Berlin. 1998–2002 Promotionsarbeit am Max-Planck-Institut für Psychiatrie in München. 2002–2004 Postdoktorand am Burnham Institute in La Jolla, CA, USA. 2004–2010 Juniorprofessor, seit 2010 Universitätsprofessor an der Universitätsmedizin der Universität Mainz.

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Moosmann, B. Redoxbiochemie des genetischen Codes. Biospektrum 23, 748–751 (2017). https://doi.org/10.1007/s12268-017-0864-7

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  • DOI: https://doi.org/10.1007/s12268-017-0864-7

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