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Bakterien-induzierte Morphogenese mariner Eukaryoten


The chemical analysis of bacteria-induced morphogenesis of marine microeukaryotes and invertebrates is of fundamental importance and provides insight into metazoan evolution and the origins of morphological complexity. In only few cases the morphogenesis-inducing bacteria could be characterized and the responsible signalling molecules identified. Using defined model systems of cross-kingdom interactions is essential to dissect the molecular mechanisms and chemical signals involved.

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  1. McFall-Ngai M, Hadfield MG, Bosch TC et al. (2013) Animals in a bacterial world, a new imperative for the life sciences. Proc Natl Acad Sci USA 110:3229–3236

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. Kuhlisch C, Pohnert G (2015) Metabolomics in chemical ecology. Nat Prod Rep 32:937–955

    CAS  Article  PubMed  Google Scholar 

  3. Selandera E, Kubanek J, Hamberg M et al. (2015) Predator lipids induce paralytic shellfish toxins in bloom-forming algae. Proc Natl Acad Sci USA 112:6395–6400

    Article  Google Scholar 

  4. Pondaven P, Gallinari M, Chollet S et al. (2007) Grazing-induced changes in cell wall silicification in a marine diatom. Protist 158:21–28

    CAS  Article  PubMed  Google Scholar 

  5. Beemelmanns C, Woznica A, Alegado RA et al. (2014) Synthesis of the rosette-inducing factor RIF-1 and analogs. J Am Chem Soc 136:10210–10213

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. Woznica A, Cantley AM, Beemelmanns C et al. (2016) Bacterial lipids activate, synergize, and inhibit a developmental switch in choanoflagellates. Proc Natl Acad Sci USA 113:7894–7899

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. Hadfield MG (2011) Biofilms and marine invertebrate larvae: what bacteria produce that larvae use to choose settlement sites. Annu Rev Mar Sci 3:453–470

    Article  Google Scholar 

  8. Wichard T (2015) Frontiers exploring bacteria-induced growth and morphogenesis in the green macroalga order Ulvales (Chlorophyta). Front Plant Sci 6:86

    PubMed  PubMed Central  Google Scholar 

  9. Tebben J, Tapiolas DM, Motti CA et al. (2011) Induction of larval metamorphosis of the coral Acropora millepora by tetrabromopyrrole isolated from a Pseudoalteromonas bacterium. PLoS One 6:e19082

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  10. Uemura D, Kita M, Arimoto H et al. (2009) Recent aspects of chemical ecology: natural toxins, coral communities, and symbiotic relationships. Pure Appl Chem 81:1093–1111

    CAS  Article  Google Scholar 

  11. Guo H, Rischer M, Sperfeld M et al. (2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem, doi: 10.1016/j.bmc.2017.06.053

    Google Scholar 

  12. Shikuma NJ, Pilhofer M, Weiss GL et al. (2014) Marine tubeworm metamorphosis induced by arrays of bacterial phage tail-like structures. Science 343:529–533

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. Freckelton ML, Nedved BT, Hadfield MG (2017) Induction of Invertebrate Larval Settlement; Different Bacteria, Different Mechanisms? Sci Rep 7:42557

    CAS  Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Christine Beemelmanns.

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Christine Beemelmanns Jahrgang 1981. 20012006 Chemiestudium (Diplom) an der RTWH Aachen. 20072010 Promotion in Organischer Chemie an der FU Berlin. 20102011 Postdoc am Tokyo Institute of Technology (Japan), DAAD-Stipendium. 20112013 Postdoc an der Harvard Medical School, USA, Leopoldina-Stipendium. Seit 2013 Nachwuchsgruppenleiterin am Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie (HKI), Jena.

Maja Rischer Jahrgang 1989. 20092012 Biologiestudium (Bachelor) an der Universität Jena, dort 20122014 Mikrobiologiestudium (Master). Seit 2014 Doktorandin an der Universität Jena.

Daniel Leichnitz Jahrgang 1990. 20092014 Chemiestudium an der FU Berlin. Seit 2015 Doktorand an der Universität Jena.

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Rischer, M., Leichnitz, D. & Beemelmanns, C. Bakterien-induzierte Morphogenese mariner Eukaryoten. Biospektrum 23, 634–637 (2017).

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