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Baukasten der Natur: neue Proteine aus konservierten Fragmenten

Abstract

Proteins evolved to be very diverse and adapted to a multitude of central cellular functions. This impressive repertoire of today’s proteins developed through duplication and recombination of smaller protein and peptide building blocks. Based on such evolutionary observations we proposed a rational design strategy in which new functional hybrids can be build from fragments of existing proteins. With this approach we are tackling the long-standing goal of complex custom-made protein design.

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Correspondence to Birte Höcker.

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Saacnicteh Toledo-Patino Biochemie- und Pharmaziestudium an der Michoacana de San Nicolas de Hidalgo Universität Morelia, Mexico, sowie Biochemie an der Universität Tübingen. 2013 Diplomarbeit am Max-Planck-Institut für Entwicklungsbiologie, Tübingen, dort seit 2014 Doktorandin in der AG „Protein-design“ und seit 2016 an der Universität Bayreuth.

Francisco Lobos 2011 Bachelor in Bioengineering an der University of Concepcion, Chile, dort 2014 Master in Biochemie und Bioinformatik. Seit 2015 Doktorand der International Max Planck Research School (IMPRS) Tübingen in der AG „Proteindesign“ am Max-Planck-Institut für Entwicklungsbiologie, Tübingen, und seit 2016 an der Universität Bayreuth.

Birte Höcker Biologiestudium an den Universitäten Göttingen und Ottawa, Kanada. 2003 Promotion im Fach Biochemie an der Universität Köln. 20032005 Postdoc am Duke Univer sity Medical Center, Durham, NC, USA. 20062016 Gruppenleiterin am Max-Planck-Institut für Entwicklungsbiologie, Tübingen. Seit 2016 W3-Professorin für Biochemie an der Universität Bayreuth. 2015 ERC Consolidator Award und Otto-Meyerhof-Preis der GBM.

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Toledo-Patino, S., Lobos, F. & Höcker, B. Baukasten der Natur: neue Proteine aus konservierten Fragmenten. Biospektrum 23, 630–633 (2017). https://doi.org/10.1007/s12268-017-0847-8

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  • DOI: https://doi.org/10.1007/s12268-017-0847-8