Highly specific peptides that bind a given target protein are useful ligands for the affinity purification of such proteins from complex biological matrices. The capability to provide this kind of peptidic ligands for the affinity purification of virtually any protein can simplify and enhance the downstream process development. The general applicability, scalability, and comparatively low costs of peptidic ligands are key features for their application in downstream purification processes.
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Paschke, M., Althoff, V. Peptidliganden zur Aufreinigung kamelider Schwere-Ketten-Antikörper. Biospektrum 23, 424–426 (2017). https://doi.org/10.1007/s12268-017-0821-5