Peptidliganden zur Aufreinigung kamelider Schwere-Ketten-Antikörper

Methoden der Proteinchemie

Abstract

Highly specific peptides that bind a given target protein are useful ligands for the affinity purification of such proteins from complex biological matrices. The capability to provide this kind of peptidic ligands for the affinity purification of virtually any protein can simplify and enhance the downstream process development. The general applicability, scalability, and comparatively low costs of peptidic ligands are key features for their application in downstream purification processes.

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Literatur

  1. [1]

    Muyldermans S (2001) Single domain camel antibodies: current status. J Biotechnol 74:277–302

    CAS  PubMed  Google Scholar 

  2. [2]

    Teillaud JL (2012) From whole monoclonal antibodies to single domain antibodies: think small. Methods Mol Biol 911:3–13

    CAS  PubMed  Google Scholar 

  3. [3]

    De Genst E, Saerens D, Muyldermans S et al. (2006) Antibody repertoire developement in camelids. Dev Comp Immunol 30:187–198

    Article  PubMed  Google Scholar 

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Correspondence to Matthias Paschke.

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Paschke, M., Althoff, V. Peptidliganden zur Aufreinigung kamelider Schwere-Ketten-Antikörper. Biospektrum 23, 424–426 (2017). https://doi.org/10.1007/s12268-017-0821-5

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