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Hypoxie – Wenn weniger (Sauerstoff) mehr (Stammzellen) macht

Physiologische Kultivierung

  • Wissenschaft · Special: Zellbiologie
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BIOspektrum Aims and scope

Abstract

The standard cell culture oxygen concentration of 21 percent O2 does not represent the physiologic environment of stem cells. Indeed, hypoxic (< 21 percent O2) conditions heavily affect cellular processes such as growth, apoptosis and energy metabolism. In the context of clinical trials a fast ex vivo expansion of stem cells while maintaining their stem cell properties is crucial. However, maintaining hypoxic conditions during cultivation is challenging and puts high requirements on laboratory equipment.

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Author information

Authors and Affiliations

  1. Department für Biotechnologie, Universität für Bodenkultur Wien, Österreich, Deutschland

    Cornelia Kasper & Dominik Egger

Authors
  1. Cornelia Kasper
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  2. Dominik Egger
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Corresponding author

Correspondence to Cornelia Kasper.

Additional information

Cornelia Kasper 1994 Diplom Chemie. 1998 Doktortitel Technische Chemie. 2007 Habilitation an der Universität Hannover, dort 2000–2011 Leiterin der Arbeitsgruppe „Zellkultur und Tissue Engineering“. Seit 2011 Universitätsprofessorin an der Universität für Bodenkultur in Wien, Österreich.

Dominik Egger 2014 M. Sc. Life Science an der Leibniz Universität Hannover. Bis 2017 Promotion an der Universität für Bodenkultur (Labor Prof. Dr. C. Kasper) in Wien, Österreich.

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Kasper, C., Egger, D. Hypoxie – Wenn weniger (Sauerstoff) mehr (Stammzellen) macht. Biospektrum 23, 404–407 (2017). https://doi.org/10.1007/s12268-017-0818-0

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  • DOI: https://doi.org/10.1007/s12268-017-0818-0

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