Regulation der Proteostase – ein Fokus auf das Ubiquitin-Proteasomen-System

Proteostase und Immunantwort

Abstract

Regulated proteolysis by the ubiquitin proteasome system (UPS) is vital for cells to preserve protein homeostasis (proteostasis). Proteotoxic stress by radical production can severely challenge proteostasis closely interconnecting redox with protein homeostasis. To counteract proteo - toxicity the capacity of the UPS is adjusted by differential expression of UPS factors and proteasome isoforms. Faulty regulation or proteasome impairment that cause an interferon response are hallmarks of many diseases and will be discussed.

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Correspondence to Elke Krüger.

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Elke Krüger 1987–1996 Biologiestudium mit anschließender Promotion bei Prof. Dr. Hecker an der Universität Greifswald. 1997–1999 Postdoktorat in Greifswald. 1999–2008 Gruppenleiterin am Institut für Biochemie an der Charité Berlin. 2008 Habilitation. 2009 W2-Professorin für Biochemie an der Charité Berlin. Seit 2017 Direktorin des Instituts für Medizinische Biochemie und Molekularbiologie, Universitätsmedizin Greifswald.

Frédéric Ebstein 2001 Diplôme d’Ètudes Approfondies (DEA) in Biologie, Universität Nantes, Frankreich; dort 2001–2005 Promotion bei Dr. M. Grégoire. Seit 2005 Postdoc am Institut für Bio chemie an der Charité-Universitätsmedizin Berlin. Seit Mai 2017 am Institut für Medizinische Biochemie und Molekularbiologie, Universitätsmedizin Greifswald.

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Ebstein, F., Krüger, E. Regulation der Proteostase – ein Fokus auf das Ubiquitin-Proteasomen-System. Biospektrum 23, 379–383 (2017). https://doi.org/10.1007/s12268-017-0812-6

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