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BIOspektrum

, Volume 23, Issue 3, pp 301–302 | Cite as

Miniaturisierte menschliche Organe auf dem Chip

  • Tobias Hasenberg
  • Eva-Maria Dehne
  • Roland Lauster
  • Uwe Marx
Anwendungen & Produkte Mikrophysiologische Systeme

Abstract

New regulations and novel substance classes made the evaluation and authorisation process of drugs, cosmetics and chemicals not only more complicated but laborious. A microphysiological system was developed as a new foundation for substance discovery and risk assessment. Its microfluidic setup allows the combination of any 3D organ model and their interaction.

Literatur

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    Maschmeyer I, Hasenberg T, Jaenicke A et al. (2015) Chipbased human liver-intestine and liver-skin co-cultures–a first step toward systemic repeated dose substance testing in vitro. Eur J Pharm Biopharm 95:77–87CrossRefPubMedGoogle Scholar
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    Marx U, Walles H, Hoffmann S et al. (2012) “Human-on-achip” developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? Altern Lab Anim 40:235–257PubMedGoogle Scholar
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    Schimek K, Busek M, Brincker S et al. (2013) Integrating biological vasculature into a multi-organ-chip microsystem. Lab Chip 13:3588–3598CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Tobias Hasenberg
    • 1
  • Eva-Maria Dehne
    • 1
  • Roland Lauster
    • 2
  • Uwe Marx
    • 1
  1. 1.TissUse GmbHBerlinDeutschland
  2. 2.Medizinische BiotechnologieTU BerlinBerlinDeutschland

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