Abstract
Anaphylaxis due to stings of honeybees and wasps is one of the most severe IgE-mediated hypersensitivity reactions. In the last years, increasing knowledge about the venom composition on a molecular level and the availability of recombinant allergens with advanced characteristics, have facilitated the development of component-resolved diagnostics. Here we will give examples for the advantages of such an approach over classical diagnostics and for potential therapeutic implications.
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Simon Blank, Maximilian Schiener, Stefanie Etzold (vorne) sowie Dennis Rußkamp und Anke Gräßel (hinten, v. l. n. r.) Die Arbeitsgruppe „Molekulare und Translatio nale Allergologie“ von Dr. Simon Blank ist seit Oktober 2013 am Zentrum für Allergie und Umwelt (Direktor: Prof. Dr. Carsten B. Schmidt-Weber), einer Gemeinschaftseinrichtung der Technischen Universität München und des Helmholtz Zentrums München, angesiedelt. Die Gruppe beschäftigt sich neben der Allergencharakterisierung und molekularen Diagnostik ebenfalls mit den Grundlagen der allergischen Immunantwort sowie der Entwicklung neuer therapeutischer Ansätze.
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Graessel, A., Schiener, M., Etzold, S. et al. Komponenten-aufgelöste Diagnostik der Hymenopterengiftallergie. Biospektrum 22, 713–716 (2016). https://doi.org/10.1007/s12268-016-0749-1
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DOI: https://doi.org/10.1007/s12268-016-0749-1