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Komponenten-aufgelöste Diagnostik der Hymenopterengiftallergie


Anaphylaxis due to stings of honeybees and wasps is one of the most severe IgE-mediated hypersensitivity reactions. In the last years, increasing knowledge about the venom composition on a molecular level and the availability of recombinant allergens with advanced characteristics, have facilitated the development of component-resolved diagnostics. Here we will give examples for the advantages of such an approach over classical diagnostics and for potential therapeutic implications.

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  1. Bilo BM, Rueff F, Mosbech H et al. (2005) Diagnosis of Hymenoptera venom allergy. Allergy 60:1339–1349

    Article  CAS  PubMed  Google Scholar 

  2. Akdis M, Akdis CA (2014) Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol 133:621–631

    Article  CAS  PubMed  Google Scholar 

  3. Ollert M, Blank S (2015) Anaphylaxis to insect venom allergens: role of molecular diagnostics. Curr Allergy Asthma Rep 15:527

    Article  CAS  Google Scholar 

  4. Blank S, Michel Y, Seismann H et al. (2011) Evaluation of different glycoforms of honeybee venom major allergen phospholipase A2 (Api m 1) produced in insect cells. Protein Pept Lett 18:415–422

    Article  CAS  PubMed  Google Scholar 

  5. Kohler J, Blank S, Muller S et al. (2014) Component resolution reveals additional major allergens in patients with honeybee venom allergy. J Allergy Clin Immunol 133:1383–1389, 1389 e1–6

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Simon Blank.

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Simon Blank, Maximilian Schiener, Stefanie Etzold (vorne) sowie Dennis Rußkamp und Anke Gräßel (hinten, v. l. n. r.) Die Arbeitsgruppe „Molekulare und Translatio nale Allergologie“ von Dr. Simon Blank ist seit Oktober 2013 am Zentrum für Allergie und Umwelt (Direktor: Prof. Dr. Carsten B. Schmidt-Weber), einer Gemeinschaftseinrichtung der Technischen Universität München und des Helmholtz Zentrums München, angesiedelt. Die Gruppe beschäftigt sich neben der Allergencharakterisierung und molekularen Diagnostik ebenfalls mit den Grundlagen der allergischen Immunantwort sowie der Entwicklung neuer therapeutischer Ansätze.

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Graessel, A., Schiener, M., Etzold, S. et al. Komponenten-aufgelöste Diagnostik der Hymenopterengiftallergie. Biospektrum 22, 713–716 (2016).

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