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Neue seitenspezifische Proteinfunktionalität mit einem Klick

  • Wissenschaft · Methoden
  • Protein Engineering
  • Published:
BIOspektrum Aims and scope

Abstract

Genetic encoding of custom designed non-canonical amino acids has emerged as one of the most versatile tools to install site-specific “click-reactive” functionalities into proteins. These non-toxic groups can readily react with suitable substances carrying a compatible clickchemistry. The technology can be used for a variety of applications, such as fluorescent labelling of protein in cells to visualize molecular machines and to custom-engineer better drugs.

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Authors and Affiliations

  1. European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit Cell Biology and Biophysics Unit, Meyerhofstraße 1, D-69117, Heidelberg, Deutschland

    Christine Koehler & Edward A. Lemke

Authors
  1. Christine Koehler
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  2. Edward A. Lemke
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Corresponding author

Correspondence to Edward A. Lemke.

Additional information

Christine Köhler Jahrgang 1981. Biotechnologiestudium an der Fachhochschule Bingen. 2006–2009 wissenschaftliche Technikerin am EMBL Heidelberg in der Gruppe Prof. Dr. D. Suck. Ab 2009 in der Gruppe bei Dr. E. Lemke, dort seit 2012 Laboratory Officer. Seit 2016 Scientific Research Manager.

Edward A. Lemke Jahrgang 1978. 1999–2000 Master of Science. Department of Chemistry and Biochemistry, University of Oklahoma, USA. 1997–2001 Diplom in Chemie, TU Berlin. 2002–2005 Promotion, Max-Planck-Institut für Biophysikalische Chemie, Göttingen. 2005–2008 Joint Research Associate, The Scripps Research Institute, La Jolla, CA, USA. Seit 2009 unabhängiger Gruppenleiter am EMBL Heidelberg, Structural and Computational Biology Unit.

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Koehler, C., Lemke, E.A. Neue seitenspezifische Proteinfunktionalität mit einem Klick. Biospektrum 22, 704–707 (2016). https://doi.org/10.1007/s12268-016-0747-3

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  • DOI: https://doi.org/10.1007/s12268-016-0747-3

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