Abstract
Archaea exhibit unique features especially with respect to their central carbohydrate metabolism characterized by many unusual pathways and enzymes with specific energetic and regulatory properties. This probably contributes to “metabolic thermoadaptation” towards high temperature environments in which many archaea reside. The unusual metabolic and adaptive properties of Archaea also possess a great potential for biotechnology, which becomes more and more accessible by systems biology approaches.
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Bräsen C, Esser D, Rauch B et al. (2014) Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation. Microbiol Mol Biol Rev 78:89–175
Kengen SW, de Bok FA, van Loo ND et al. (1994) Evidence for the operation of a novel Embden-Meyerhof pathway that involves ADP-dependent kinases during sugar fermentation by Pyrococcus furiosus. J Biol Chem 269:17537–17541
Hansen T, Oehlmann M, Schonheit P (2001) Novel type of glucose-6-phosphate isomerase in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol 183:3428–3435
Brunner NA, Brinkmann H, Siebers B et al. (1998) NAD+- dependent glyceraldehyde-3-phosphate dehydrogenase from Thermoproteus tenax. The first identified archaeal member of the aldehyde dehydrogenase superfamily is a glycolytic enzyme with unusual regulatory properties. J Biol Chem 273:6149–6156
Ahmed H, Ettema TJ, Tjaden B et al. (2005) The semiphosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation. Biochem J 390:529–540
Danson MJ, Hough DW (2005) Promiscuity in the Archaea: the enzymology of their metabolic pathways. Biochemist 27:17–21
Kouril T, Wieloch P, Reimann J et al. (2013) Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2. FEBS J 280:1126–1138
Orita I, Sato T, Yurimoto H et al. (2006) The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis. J Bacteriol 188:4698–4704
Esser D, Pham KT, Reimann J et al. (2012) Change of carbon source causes dramatic effects in the phospho-proteome of the Archaeon Sulfolobus solfataricus. J Proteome Res 11:4823–4822
Kouril T, Esser D, Kort J et al. (2013) Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus. FEBS J 280:1126–1138
Say RF, Fuchs G (2010) Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme. Nature 464:1077–1081
Ulas T, Riemer SA, Zaparty M et al. (2012) Genome-scale reconstruction and analysis of the metabolic network in the hyperthermophilic archaeon Sulfolobus solfataricus. PloS One 7:e43401
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Bettina Siebers Biologiestudium an den Universitäten Münster und Osnabrück. 1995 Promotion in Mikrobiologie, Uni versität Essen. 1998–1999 Forschungsaufenthalt Virginia Polytechnic Institute and State University, Blacksburg, USA. 1999–2004 Gruppenleiterin Mikrobiologie I, Universität Duisburg-Essen. Seit 2008 Professorin für Molekulare Enzymtechnologie und Biochemie, Biofilm Centre, Fakultät für Chemie, Universität Duisburg-Essen.
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Siebers, B. Kohlenhydratstoffwechsel in Archaea–Besonderheiten und Herausforderung. Biospektrum 22, 455–458 (2016). https://doi.org/10.1007/s12268-016-0710-3
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DOI: https://doi.org/10.1007/s12268-016-0710-3