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BIOspektrum

, Volume 22, Issue 4, pp 374–377 | Cite as

Synthetische subzelluläre Kompar - timente in eukaryotischen Zellen

  • Mara Reifenrath
  • Joanna Tripp
  • Mislav Oreb
  • Eckhard BolesEmail author
Wissenschaft · Special: Zellbiologie Künstliche Kompartimentierung
  • 71 Downloads

Abstract

Genetic engineering of metabolic pathways for biotechnological purposes is often hampered by factors like slow diffusion rates, competing pathways or secretion of intermediates. To bypass these limitations, compartimentalization of enzymatic reactions is a promising approach. For this, enzymes can either be arranged in complexes or they can be isolated in coated subcellular compartments. We are developing new concepts to assemble various enzymes in protein supercomplexes and to relocate metabolic pathways into synthetic organelles.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Mara Reifenrath
    • 1
  • Joanna Tripp
    • 1
  • Mislav Oreb
    • 1
  • Eckhard Boles
    • 1
    Email author
  1. 1.Institut für Molekulare BiowissenschaftenGoethe-Universität FrankfurtFrankfurt a. M.Germany

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