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Chromosom in Schleifen: SMC-Kom - plexe als molekulare Kabelbinder?

  • Wissenschaft
  • Chromosomenorganisation
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Abstract

Chromosome compaction is an essential prerequisite for the faithful segregation of chromosomes during cell division. SMC proteins promote the compaction and resolution of sister DNA molecules. They form ring-like structures that are thought to tie selected segments of chromosomes together. The underlying molecular mechanisms, however, are still poorly understood. Insights gained for the bacterial ancestor of SMC provide an excellent basis for our general understanding of these highly conserved molecular machines.

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Authors and Affiliations

  1. Chromosomale Organisation und Dynamik, Max-Planck-Institut für Biochemie, Am Klopferspitz 18, D-82152, Martinsried, Germany

    Larissa Wilhelm & Stephan Gruber

Authors
  1. Larissa Wilhelm
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  2. Stephan Gruber
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Corresponding author

Correspondence to Stephan Gruber.

Additional information

Larissa Wilhelm Jahrgang 1989. 2007–2012 Studium der Molekularen Biotechnologie an der FH Campus Wien, Österreich. Seit 2013 Doktorandin in der Arbeitsgruppe von S. Gruber, Max-Planck-Institut für Biochemie, Martinsried.

Stephan Gruber Jahrgang 1978. 1996–2001 Chemiestudium an der Universität Wien, Österreich. 2005 Promotion am Institut für Molekulare Pathologie (IMP), Wien. Bis 2010 Post - doktorand am Zentrum für bakterielle Zellbiologie, Newcastle upon Tyne, UK. Seit 2010 Gruppenleiter am Max-Planck-Institut für Biochemie, Martinsried. Ab August 2016 an der Universität Lausanne, Schweiz.

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Wilhelm, L., Gruber, S. Chromosom in Schleifen: SMC-Kom - plexe als molekulare Kabelbinder?. Biospektrum 22, 356–358 (2016). https://doi.org/10.1007/s12268-016-0696-x

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  • DOI: https://doi.org/10.1007/s12268-016-0696-x

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