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Fluorierte Tenside und native Nano discs für die Membranproteinforschung

  • Wissenschaft · Methoden
  • Neue Membranmimetika
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Abstract

Integral membrane proteins are important but challenging research subjects. Various membrane mimetics have been developed that should preserve the native structure and function of membrane proteins while rendering them amenable to biophysical, biochemical, and structural investigations. Here, we summarize recent progress with fluorinated surfactants and amphiphilic copolymers, two unconventional membrane mimetics that possess considerable advantages over canonical detergents or lipid vesicles.

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Authors and Affiliations

  1. Molekulare Biophysik, Technische Universität Kaiserslautern, Erwin-Schrödinger-Straße 13, D-67663, Kaiserslautern, Deutschland

    Carolyn Vargas, Erik Frotscher, Rodrigo Cuevas Arenas, Anne Grethen & Sandro Keller

Authors
  1. Carolyn Vargas
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  2. Erik Frotscher
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  3. Rodrigo Cuevas Arenas
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  4. Anne Grethen
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  5. Sandro Keller
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Corresponding author

Correspondence to Sandro Keller.

Additional information

Sandro Keller, Erik Frotscher, Carolyn Vargas, Rodrigo Cuevas Arenas und Anne Grethen (v. l. n. r.)

Carolyn Vargas Jahrgang 1974. Chemiestudium an der University of the Philippines Diliman. 2003–2008 wissenschaftliche Mitarbeiterin am Leibniz-Institut für Molekulare Pharmakologie (FMP) Berlin und 2008–2009 bei Evotec AG. 2009 Promotion an der Universität Halle-Wittenberg. Seit 2010 wissenschaftliche Mitarbeiterin in der Abteilung Molekulare Biophysik an der TU Kaiserslautern.

Erik Frotscher Jahrgang 1988. Biologiestudium an der TU Kaiserslautern, dort seit 2014 Promotion in der Abteilung Molekulare Bio physik.

Rodrigo Cuevas Arenas Jahrgang 1985. Biologiestudium an der Pontificia Universidad Católica de Chile und an der TU Kaiserslautern. Seit 2014 Promotion in der Abteilung Molekulare Biophysik an der TU Kaiserslautern.

Anne Grethen Jahrgang 1989. Biophysikstudium an der TU Kaiserslautern, dort seit 2016 Promotion in der Abteilung Molekulare Bio physik.

Sandro Keller Jahrgang 1978. Studium am Biozentrum der Universität Basel, Schweiz, mit Spezialisierung in Biophysikalischer Chemie. 2006 Promotion an der Universität Halle-Wittenberg. 2006–2009 Nachwuchsgruppenleiter am Leibniz-Institut für Molekulare Pharmakologie (FMP) Berlin. 2009–2015 Juniorprofessor und seit 2015 Professor für Molekulare Biophysik an der TU Kaiserslautern.

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Vargas, C., Frotscher, E., Cuevas Arenas, R. et al. Fluorierte Tenside und native Nano discs für die Membranproteinforschung. Biospektrum 22, 140–142 (2016). https://doi.org/10.1007/s12268-016-0667-2

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  • DOI: https://doi.org/10.1007/s12268-016-0667-2

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