BIOspektrum

, Volume 22, Issue 1, pp 62–64

CRISPR in der biotechnologischen Forschung und Entwicklung

  • Ümit Pul
  • Jörg Mampel
  • Christian Zurek
  • Michael Krohn
Anwendungen & Produkte Genomeditierung

DOI: 10.1007/s12268-016-0659-2

Cite this article as:
Pul, Ü., Mampel, J., Zurek, C. et al. Biospektrum (2016) 22: 62. doi:10.1007/s12268-016-0659-2

Abstract

The discovery of programmable double-stranded DNA specific nucleases derived from the prokaryotic immunity systems CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has opened a new era of genome editing and its applications in industrial biotechnology. Simple reprogramming of the DNA-specificity of CRISPR nucleases by RNAs allows the engineering of novel eukaryotic screening or producer cells through gene knock-out, chromosomal deletion and the regulation of gene expression.

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Ümit Pul
    • 1
  • Jörg Mampel
    • 1
  • Christian Zurek
    • 1
  • Michael Krohn
    • 1
  1. 1.B.R.A.I.N Aktiengesellschaft, BioActives & Performance BiologicalsZwingenbergDeutschland

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