Skip to main content
Log in

Der Beitrag der Gene beim Parkinson-Syndrom

  • Wissenschaft
  • Genetische Medizin
  • Published:
BIOspektrum Aims and scope


In the past two decades, a number of genetic causes of Parkinson disease (PD) have been elucidated. This includes both monogenic forms in which a single mutation is sufficient to cause PD and genetic risk factors. The latter only increase the susceptibility for PD and additional, likely environmental hits are necessary to develop the disease. PD genes such as LRRK2 and Parkin often encode proteins involved in mitochondrial function, protein degradation, or response to oxidative stress.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Seeman P, Tinazzi M (2013) Loss of dopamine neuron terminals in antipsychotic-treated schizophrenia; relation to tardive dyskinesia. Prog Neuropsychopharmacol Biol Psychiatry 44:178–183

    Article  CAS  PubMed  Google Scholar 

  2. Dickson DW (2012) Parkinson’s disease and parkinsonism: neuropathology. Cold Spring Harb Perspect Med 2, doi: 10.1101/cshperspect.a009258

  3. Bach JP, Ziegler U, Deuschl G et al. (2011) Projected numbers of people with movement disorders in the years 2030 and 2050. Mov Disord 26:2286–2290

    Article  PubMed  Google Scholar 

  4. Polymeropoulos MH, Lavedan C, Leroy E et al. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 276:2045–2047

    Article  CAS  PubMed  Google Scholar 

  5. Trinh J, Farrer M (2013) Advances in the genetics of Parkinson disease. Nat Rev Neurol 9:445–454

    Article  CAS  PubMed  Google Scholar 

  6. Verstraeten A, Theuns J, Van Broeckhoven C (2015) Progress in unraveling the genetic etiology of Parkinson disease in a genomic era. Trends Genet 31:140–149

    Article  CAS  PubMed  Google Scholar 

  7. Lohmann K, Klein C (2014) Next generation sequencing and the future of genetic diagnosis. Neurotherapeutics 11:699–707

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Nalls MA, Pankratz N, Lill CM et al. (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. Nat Genet 46:989–993

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Haelterman NA, Yoon WH, Sandoval H et al. (2014) A mitocentric view of Parkinson’s disease. Annu Rev Neurosci 37:137–159

    Article  CAS  PubMed  Google Scholar 

  10. Rakovic A, Grünewald A, Kottwitz J et al. (2011) Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One 6:e16746

    Article  Google Scholar 

  11. Zavodszky E, Seaman MN, Moreau K et al. (2014) Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy. Nat Commun 5:3828

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Langston JW, Ballard P, Tetrud JW et al. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979–980

    Article  CAS  PubMed  Google Scholar 

  13. Marras C, Lohmann K, Lang A et al. (2012) Fixing the broken system of genetic locus symbols: Parkinson disease and dystonia as examples. Neurology 78:1016–1024

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Katja Lohmann.

Additional information

Katja Lohmann Jahrgang 1977. 19952000 Biologiestudium an den Universitäten Dresden und Halle. 20012002 Forschungsaufenthalt am Massachusetts General Hospital, Boston, USA. 2003 Promotion am Institut für Humangenetik, Universität zu Lübeck. 2005 Postdoc an der Oregon Health and Science University, Portland, USA. 2010 Habilitation, Lübeck. Seit 2010 Arbeits gruppenleiterin und seit 2013 stellvertretende Leiterin des neu gegründeten Instituts für Neurogenetik an der Universität zu Lübeck.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lohmann, K. Der Beitrag der Gene beim Parkinson-Syndrom. Biospektrum 21, 699–702 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI: