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BIOspektrum

, Volume 21, Issue 7, pp 699–702 | Cite as

Der Beitrag der Gene beim Parkinson-Syndrom

  • Katja Lohmann
Wissenschaft Genetische Medizin
  • 62 Downloads

Abstract

In the past two decades, a number of genetic causes of Parkinson disease (PD) have been elucidated. This includes both monogenic forms in which a single mutation is sufficient to cause PD and genetic risk factors. The latter only increase the susceptibility for PD and additional, likely environmental hits are necessary to develop the disease. PD genes such as LRRK2 and Parkin often encode proteins involved in mitochondrial function, protein degradation, or response to oxidative stress.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Institut für NeurogenetikUniversität zu LübeckLübeckDeutschland

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