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Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle

Abstract

Protein degradation by the ubiquitin-proteasome system (UPS) is essential for life. Degradation of enzymes and other regulatory proteins like activators or inhibitors is crucial for a multitude of cellular processes. Prominent examples are cell cycle progression or regulation of metabolic pathways. Furthermore, elimination of misfolded proteins is essential to prevent disturbance of cell functions.

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Correspondence to Dieter H. Wolf.

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Ruth Menssen 19881993 Biochemiestudium an der FU Berlin; dort 19931997 Promotion. 19982002 Postdoktorandin am Institut für Industrielle Genetik der Uni versität Stuttgart. 20032007 Elternzeit. 20082010 Stipendiatin des Schlieben- Lange-Programms des Landes Baden-Württemberg. Seit 2011 Projektleiterin am Institut für Biochemie der Universität Stuttgart.

Dieter H. Wolf 19631968 Chemiestudium an der TU Karlsruhe und TU München. 19681972 Promotion am Institut für Biochemie an der Universität Freiburg. 19731975 Postdoktorand in der Abteilung für Genetik an der Cornell University, Ithaca, NY, USA. 19751980 Gruppenleiter am Institut für Biochemie der Universität Freiburg und Habilitation; ebenda 19801989 Professor. 19892011 Lehrstuhlinhaber und Direktor des Instituts für Biochemie der Universität Stuttgart. Seit 2011 Professor i. R. und Leiter einer Arbeitsgruppe zum Ubiquitin-Proteasom-System.

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Menssen, R., Wolf, D.H. Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle. Biospektrum 21, 608–611 (2015). https://doi.org/10.1007/s12268-015-0621-8

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  • DOI: https://doi.org/10.1007/s12268-015-0621-8