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Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle

  • Wissenschaft
  • Proteasom-abhängiger Proteinabbau
  • Published:
BIOspektrum Aims and scope

Abstract

Protein degradation by the ubiquitin-proteasome system (UPS) is essential for life. Degradation of enzymes and other regulatory proteins like activators or inhibitors is crucial for a multitude of cellular processes. Prominent examples are cell cycle progression or regulation of metabolic pathways. Furthermore, elimination of misfolded proteins is essential to prevent disturbance of cell functions.

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Authors and Affiliations

  1. Institut für Biochemie, Universität Stuttgart, Pfaffenwaldring 55, D-70569, Stuttgart, Deutschland

    Ruth Menssen & Dieter H. Wolf

Authors
  1. Ruth Menssen
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  2. Dieter H. Wolf
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Corresponding author

Correspondence to Dieter H. Wolf.

Additional information

Ruth Menssen 1988–1993 Biochemiestudium an der FU Berlin; dort 1993–1997 Promotion. 1998–2002 Postdoktorandin am Institut für Industrielle Genetik der Uni versität Stuttgart. 2003–2007 Elternzeit. 2008–2010 Stipendiatin des Schlieben- Lange-Programms des Landes Baden-Württemberg. Seit 2011 Projektleiterin am Institut für Biochemie der Universität Stuttgart.

Dieter H. Wolf 1963–1968 Chemiestudium an der TU Karlsruhe und TU München. 1968–1972 Promotion am Institut für Biochemie an der Universität Freiburg. 1973–1975 Postdoktorand in der Abteilung für Genetik an der Cornell University, Ithaca, NY, USA. 1975–1980 Gruppenleiter am Institut für Biochemie der Universität Freiburg und Habilitation; ebenda 1980–1989 Professor. 1989–2011 Lehrstuhlinhaber und Direktor des Instituts für Biochemie der Universität Stuttgart. Seit 2011 Professor i. R. und Leiter einer Arbeitsgruppe zum Ubiquitin-Proteasom-System.

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Menssen, R., Wolf, D.H. Ubiquitin-Proteasom-gesteuerte Regulation und Qualitätskontrolle der Zelle. Biospektrum 21, 608–611 (2015). https://doi.org/10.1007/s12268-015-0621-8

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  • DOI: https://doi.org/10.1007/s12268-015-0621-8

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