Skip to main content
Log in

Membrandomänen in Bakterien - Ordnung muss sein

  • Wissenschaft
  • Lipid rafts
  • Published:
BIOspektrum Aims and scope

Abstract

Biological membranes show a high degree of lateral organization. Proteins and lipids are arranged in spatio-temporal domains, termed lipid rafts. Bacterial lipid rafts are stabilized by flotillins and harbor a distinct set of proteins involved in transport, signal transduction, energy metabolism, cell wall homeostasis, and protein secretion. Bacterial model organisms such as Bacillus subtilis emerge as excellent tools to address fundamental questions related to membrane compartmentalization.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Singer SJ, Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175:720–731

    Article  CAS  PubMed  Google Scholar 

  2. Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569–572

    Article  CAS  PubMed  Google Scholar 

  3. Huber TB, Schermer B, Müller RU et al. (2006) Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103:17079–17086

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Bramkamp M, Lopez D (2015) Exploring the existence of lipid rafts in bacteria. Microbiol Mol Biol Rev 79:81–100

    Article  PubMed Central  PubMed  Google Scholar 

  5. Mileykovskaya E, Dowhan W (2009) Cardiolipin membrane domains in prokaryotes and eukaryotes. Biochim Biophys Acta 1788:2084–2091

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Jones CW, Armitage JP (2015) Positioning of bacterial chemoreceptors. Trends Microbiol 23:247–256

    Article  CAS  PubMed  Google Scholar 

  7. Schneider J, Klein T, Mielich-Süss B et al. (2015) Spatio-temporal remodeling of functional membrane microdomains organizes the signaling networks of a bacterium. PLoS Genet 11:e1005140

    Article  PubMed Central  PubMed  Google Scholar 

  8. Bach JN, Bramkamp M (2015) Dissecting the molecular properties of prokaryotic flotillins. PloS One 10:e0116750

    Article  PubMed Central  PubMed  Google Scholar 

  9. Donovan C, Bramkamp M (2009) Characterization and subcellular localization of a bacterial flotillin homologue. Microbiology 155:1786–1799

    Article  CAS  PubMed  Google Scholar 

  10. Bach JN, Bramkamp M (2013) Flotillins functionally organize the bacterial membrane. Mol Microbiol 88:1205–1217

    Article  CAS  PubMed  Google Scholar 

  11. Yepes A, Schneider J, Mielich B et al. (2012) The biofilm formation defect of a Bacillus subtilis flotillin-defective mutant involves the protease FtsH. Mol Microbiol 86:457–471

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. López D, Kolter R (2010) Functional microdomains in bacterial membranes. Genes Dev 24:1893–1902

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marc Bramkamp.

Additional information

Marc Bramkamp 19931998 Biologiestudium an der Universität Osnabrück. 19971998 Diplomarbeit am Helmholtz-Zentrum für Infektionsforschung an der Universität Braunschweig. 19992003 Promotion in Osna brück. 20042006 Postdoc an der University of Oxford, UK. 20062012 Gruppen leiter am Institut für Biochemie der Universität zu Köln. 2011 Habilitation für das Fach Biochemie. Seit 2012 Professor für Mikrobiologie an der LMU München.

Juri N. Bach 20052009 Biologiestudium (Bachelor) und 20092011 Biologiestudium (Master) an der Universität zu Köln. 20112015 Promotion in Mikrobiologie an der LMU München, dort seit 2015 Postdoc in der AG Bramkamp.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bach, J.N., Bramkamp, M. Membrandomänen in Bakterien - Ordnung muss sein. Biospektrum 21, 600–603 (2015). https://doi.org/10.1007/s12268-015-0619-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-015-0619-2

Navigation