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Architektur eines Heterochromatinkomplexes

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  • Genregulation
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Abstract

The regulation of gene expression in eukaryotes is achieved by differential chromatin packaging of the genome. Heterochromatin constitutes a repressive type of chromatin in which non-histone proteins bind to the chromatin fibre and restrict gene expression. The silent information regulator (SIR) complex from Saccharomyces cerevisiae serves as a model for eukaryotic heterochromatin. Here, our current structural knowledge of SIR-mediated chromatin is discussed.

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Authors and Affiliations

  1. Institut für Biologie, Humboldt-Universität zu Berlin, Chaußseestraße 117, D-10115, Berlin, Deutschland

    Ann E. Ehrenhofer-Murray

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  1. Ann E. Ehrenhofer-Murray
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Correspondence to Ann E. Ehrenhofer-Murray.

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Ann E. Ehrenhofer-Murray 1991 Diplom, 1994 Promotion an der ETH Zürich, Schweiz. 1994–1997 Postdoc an der Uni versity of California, Berkeley, USA. 1997–2004 Arbeitsgruppenleiterin am Max-Planck-Institut für Molekulare Genetik, Berlin. 2004–2005 Profeßsur für Genetik an der Universität Gießen. 2005–2013 Professur für Genetik an der Uni - versität Duisburg-Essen. Seit 2013 Professur für Molekulare Zellbiologie an der HU Berlin.

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Ehrenhofer-Murray, A.E. Architektur eines Heterochromatinkomplexes. Biospektrum 21, 597–599 (2015). https://doi.org/10.1007/s12268-015-0618-3

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  • DOI: https://doi.org/10.1007/s12268-015-0618-3

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