Rekonstitution biologischer Selbstorganisation in vitro
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The Escherichia coli Min proteins select the cell middle for division by oscillating between the cell poles where they inhibit the divisome protein FtsZ. Reconstitution of Min proteins on a lipid membrane in vitro yields their self-organization into surface waves. In biomimetic compartments, pole-to-pole oscillations can be obtained which direct FtsZ to the middle. This establishes bottom-up synthetic biology as a promising approach to reconstitute complex dynamics and spatial cues in vitro.
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