Abstract
Phosphoinositides (PIs) serve as signposts for membrane traffic and cell signalling. Clathrin-mediated endocytosis from the cell surface is initiated by phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2]. The following maturation of endocytic structures and their progression towards the endosomal system is accompanied by the generation of phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and the dephosphorylation of PI(4,5)P2. Here we summarize the mechanism of PI conversion and its implications for human disease.
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Volker Haucke Jahrgang 1968. Biochemie- und Molekularbiologiestudium an der FU Berlin und der Universität Basel, Schweiz. 1997 Promotion am Biozentrum der Universität Basel. 1997–2000 Postdoc bei Prof. Dr. P. De Camilli, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA. 2000–2003 Leiter einer unabhängigen Nachwuchsgruppe und Habilitation an der Universität Göttingen. 2003–2011 Professor für Biochemie an der FU Berlin, seit 2008 Kooptation an der Charité Universitätsmedizin Berlin. Seit 2012 Professor für Molekulare Pharmakologie an der FU Berlin und Direktor des Leibniz-Instituts für Molekulare Pharmakologie, Berlin.
Michael Krauß Jahrgang 1970. Biochemiestudium an der Universität Bayreuth und der FU Berlin. 2000 Promotion an der FU Berlin. 2000–2007 Postdoc bei Prof Dr. V. Haucke an der Universität Göttingen und der FU Berlin. 2007–2012 Juniorprofessor für Biochemie an der FU Berlin. Seit 2012 Gruppenleiter am Leibniz-Institut für Molekulare Pharmakologie, Berlin.
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Krauss, M., Haucke, V. Panta rhei an der Plasmamembran: Phosphoinositlipide in der Endozytose. Biospektrum 20, 607–610 (2014). https://doi.org/10.1007/s12268-014-0492-4
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DOI: https://doi.org/10.1007/s12268-014-0492-4