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BIOspektrum

, Volume 20, Issue 4, pp 395–399 | Cite as

R-Spondine: Einblicke in die Potenzierung der Wnt-Signaltransduktion

  • Matthias ZebischEmail author
  • E. Yvonne Jones
Wissenschaft · Special: Zellbiologie Strukturbiologie
  • 56 Downloads

Abstract

Intercellular signalling by Wnt morphogenetic proteins is subject to a multi-layered system of regulation. The four secreted R-spondin proteins potentiate Wnt signalling in vertebrates. They are involved in embryogenesis, adult stem cell biology and cancer progression and have been proven essential for ex vivo culturing of organoids. Recent research has generated profound new insights into how R-spondins function to stabilize Wnt receptors of the Frizzled family at the cell surface.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Structural Biology (Strubi), Henry Wellcome Trust Centre for Human GeneticsUniversity of OxfordOxfordUK
  2. 2.The Division of Structural BiologyThe Henry Wellcome Building for Genomic MedicineOxfordUK

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