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Transkriptom-Sequenzierung in der Alternsforschung

Biologie des Alterns

  • Wissenschaft · Special: Next Generation Sequencing
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Abstract

With the advent of next-generation sequencing technologies transcriptome sequencing (RNA-seq) became widely used to study the genetic background of ageing processes and related diseases. We describe the power of this method in the study of two novel age research model organisms, the short-lived killifish Nothobranchius furzeri and the long-lived naked mole rat Heterocephalus glaber. A third example illustrates the utility of RNA-seq in a multispecies approach elucidating the role of mild stress in healthy ageing.

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Correspondence to Stefan Taudien.

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Matthias Platzer Jahrgang 1954. Medicobiologiestudium am 2. Medizinischen Institut, Moskau. 1985 Promotion, 2006 Habilitation an der Universität Jena im Fach Genetik. Seit 2000 Arbeitsgruppenleiter Genom analyse am Leibniz-Institut für Altersforschung — Fritz-Lipmann-Institut (FLI), Jena.

Stefan Taudien Jahrgang 1958. Chemiestudium an der HU Berlin. 1992 Promotion, 1993–1994 Postdoc am Institut de Chimie Moléculaire, Orsay, Université Paris-Sud. Seit 1995 Wissenschaftler am Institut für Molekulare Biotechnologie, jetzt Fritz-Lipmann-Institut (FLI), Jena.

Karol Szafranski Jahrgang 1970. Biologiestudium an der Universität Düsseldorf. 2002 Promotion, 2002-2004 Postdoc am Institut für Molekulare Biotechnologie, jetzt Fritz-Lipmann-Institut (FLI), Jena; 2004–2005 am Center for Bioinformatics der University of Pennsylvania, Philadelphia, USA. Seit 2005 Wissenschaftler am FLI.

Kathrin Reichwald Jahrgang 1969. Biologiestudium an den Universitäten Jena und Manchester, UK. 2003 Promotion, 2004–2006 Postdoc an der Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie — Rheinische Kliniken Essen. Seit 2006 Projektleiterin am Fritz-Lipmann-Institut (FLI), Jena.

Marco Groth Jahrgang 1978. Biotechnologiestudium an der Fachhochschule Jena (Ernst-Abbe-Fachhochschule). 2008 Promotion an der Universität Leipzig. Seit 2009 Wissenschaftler am Fritz-Lipmann-Institut (FLI), Jena.

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Groth, M., Reichwald, K., Szafranski, K. et al. Transkriptom-Sequenzierung in der Alternsforschung. Biospektrum 20, 163–166 (2014). https://doi.org/10.1007/s12268-014-0423-4

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  • DOI: https://doi.org/10.1007/s12268-014-0423-4

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