Abstract
The acetylation of the Nɛ-amino group of lysine residues is a long-known post-translational modification of proteins. Initially discovered on histones many more lysine acetylation sites have been found throughout the proteomes of several organisms. This article focuses on past and present discoveries of the function and abundance of this evolutionary highly conserved protein modification.
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Literatur
Gershey EL, Vidali G, Allfrey VG (1968) Chemical studies of histone acetylation. J Biol Chem 243:5018–5022
Choudhary C, Kumar C, Gnad F et al. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325:834–840
Schwarzer D (2010) Chemical tools in chromatin research. J Pept Sci 16:530–537
Starai VJ, Celic I, Cole RN et al. (2002) Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science 298:2390–2392
Thao S, Escalante-Semerena JC (2011) Control of protein function by reversible Nɛ-lysine acetylation in bacteria. Curr Opin Microbiol 14:200–204
Kim SC, Sprung R, Chen Y et al. (2006) Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 23:607–618
Yu BJ, Kim JA, Moon JH et al. (2008) The diversity of lysine-acetylated proteins in Escherichia coli. J Microbiol Biotechnol 18:1529–1536
Zhang J, Sprung R, Pei J et al. (2009) Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteom 2:215–225
Finkemeier I, Laxa M, Miguet L et al. (2011) Proteins of diverse function and subcellular location are lysine acetylated in Arabidopsis. Plant Physiol 155:1779–1790
Wu X, Oh MH, Schwarz EM et al. (2011) Lysine acetylation is a widespread protein modification for diverse proteins in Arabidopsis. Plant Physiol 155:1769–1778
Wang Q, Zhang Y, Yang C et al. (2010) Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327:1004–1007
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Finkemeier, I., Schwarzer, D. Lysin-Acetylierung: eine altbekannte Proteinmodifikation in neuem Licht. Biospektrum 19, 810–812 (2013). https://doi.org/10.1007/s12268-013-0392-z
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DOI: https://doi.org/10.1007/s12268-013-0392-z