Abstract
The proteinogenic amino acid proline has multiple functions in living cells. Depending on whether it is used as a building block in proteins, as a nutrient, or as an osmostress protectant, the cytoplasmic proline con-centration required for these tasks varies dramatically. The soil bacterium Bacillus subtilis solves this problem by precisely regulating and highly integrating catabolic, anabolic, and stress protective processes.
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Moses S, Sinner T, Zaprasis A et al. (2012) Proline utilization by Bacillus subtilis: uptake and catabolism. J Bacteriol 194:745–758
Belitsky BR (2011) Indirect repression by Bacillus subtilis CodY via displacement of the activator of the proline utilization operon. J Mol Biol 413:321–336
Brill J, Hoffmann T, Putzer H et al. (2011) T-box-mediated control of the anabolic proline biosynthetic genes of Bacillus subtilis. Microbiology 157:977–987
Hoffmann T, Wensing A, Brosius M et al. (2013) Osmotic control of opuA expression in Bacillus subtilis and its modulation in response to intracellular glycine betaine and proline pools. J Bacteriol 195:510–522
Brill J, Hoffmann T, Bleisteiner M et al. (2011) Osmotically controlled synthesis of the compatible solute proline is critical for cellular defense of Bacillus subtilis against high osmolarity. J Bacteriol 193:5335–5346
Hoffmann T, von Blohn C, Stanek A et al. (2012) Synthesis, release, and recapture of compatible solute proline by osmotically stressed Bacillus subtilis cells. Appl Environ Microbiol 78:5753–5762
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Tamara Hoffmann 1990–1995 Biologiestudium an den Universitäten Gießen und Marburg. 1995–1998 Promotion am Institut für Biochemie der Universität Freiburg. 1999 Postdoc am Max-Planck-Institut für terrestrische Mikrobiologie, Marburg. Seit 1999 wissenschaftliche Angestellte am Fachbereich Biologie (Molekulare Mikrobiologie) der Universität Marburg.
Erhard Bremer 1974–1980 Biologiestudium an der Universität Tübingen. 1980–1981 Promotion am Max-Planck-Institut für Biologie und der Universität Tübingen. 1982–1984 Postdoc am National Cancer Institute, Frederick, MD, USA. 1984–1992 Hochschulassistent/Dozent (C1/C2) an der Universität Konstanz. 1992–1995 Arbeitsgruppenleiter (C3) am Max-Planck-Institut für terrestrische Mikrobiologie, Marburg. Seit 1995 Professor (C4) für molekulare Mikrobiologie an der Universität Marburg.
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Hoffmann, T., Bremer, E. Prolin — vielfältig wie ein Schweizer Taschenmesser. Biospektrum 19, 723–725 (2013). https://doi.org/10.1007/s12268-013-0381-2
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DOI: https://doi.org/10.1007/s12268-013-0381-2