Skip to main content
SpringerLink
Log in

Alkoholabhängigkeit und Epigenetik

  • Wissenschaft
  • Suchterkrankungen
  • Published:
BIOspektrum Aims and scope

Abstract

In the last years neurobiological investigations have lead to new insights in the pathophysiological mechanisms underlying addictive behaviour, particularly alcohol dependence. This included results regarding specific changes in the epigenetic regulation, particularly alterations of DNA methylation patterns in specific candidate genes. These studies may help to bridge the gap between genetic and psychosocial/clinical research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Rodenhiser D, Mann M (2006) Epigenetics and human disease: translating basic biology into clinical applications. Cmaj 174:341–348

    Article  PubMed  Google Scholar 

  2. Hillemacher T, Frieling H, Moskau S et al. (2008) Global DNA methylation is influenced by smoking behaviour. Eur Neuropsychopharmacol 18:295–298

    Article  PubMed  CAS  Google Scholar 

  3. Hillemacher T, Frieling H, Hartl T et al. (2009) Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. J Psychiatr Res 43:388–392

    Article  PubMed  Google Scholar 

  4. Hillemacher T, Frieling H, Luber K et al. (2009) Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal. Psychoneuroendocrinology 34:555–560

    Article  PubMed  CAS  Google Scholar 

  5. Heberlein A, Muschler M, Frieling H et al. (2013) Epigenetic down regulation of nerve growth factor during alcohol withdrawal. Addict Biol 18:508–510

    Article  PubMed  CAS  Google Scholar 

  6. Haschemi Nassab M, Rhein M, Hagemeier L et al. (2013) Allele-dependent ALDH2 promoter methylation change in the course of alcohol detoxification: insights into a genetic-epigenetic interaction. (eingereicht)

    Google Scholar 

  7. Buchholz V, Kotsiari A, Bleich S et al. (2013) Nature meets nurture: the importance of epigenetics for the aetiology of psychiatric diseases. Fortschr Neurol Psychiatr 81:368–380

    Article  PubMed  CAS  Google Scholar 

  8. Hillemacher T, Frieling H, Muschler MA et al. (2007) Homocysteine and epigenetic DNA methylation: a biological model for depression? Am J Psychiatry 164:1610

    Article  PubMed  Google Scholar 

  9. Abdolmaleky HM, Cheng KH, Russo A et al. (2005) Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 134:60–66

    Google Scholar 

  10. Tadic A, Muller-Engling L, Schlicht KF et al. (2013) Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol Psychiatry, doi: 10.1038/mp.2013.58

    Google Scholar 

  11. Herceg Z, Hainaut P (2007) Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis. Mol Oncol 1:26–41

    Article  PubMed  CAS  Google Scholar 

  12. Baylin SB (2005) DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol 2Suppl 1:S4–11

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Psychiatrie, Sozial Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Hannover, Germany

    Thomas Hillemacher & Helge Frieling

  2. Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie, Zentrum für Seelische Gesundheit Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany

    Thomas Hillemacher

Authors
  1. Thomas Hillemacher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Helge Frieling
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Hillemacher.

Additional information

Thomas Hillemacher Medizinstudium an den Universitäten Erlangen und Córdoba, Spanien. 2002 Promotion, 2006 Habilitation an der Medizinischen Fakultät der Universität Erlangen-Nürnberg. 2000–2006 Facharztausbildung für Psychiatrie und Psychotherapie am Universitätsklinikum Erlangen. 2006–2008 Oberarzt am Universitätsklinikum Erlangen. Seit 2008 Leitender Oberarzt und stellvertretender Klinikdirektor an der Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie an der Medizinischen Hochschule Hannover.

Helge Frieling Humanmedizinstudium an den Universitäten Greifswald und Siena, Italien. 2005 Promotion, 2009 Habiliatation an der Medizinischen Fakultät der Universität Erlangen-Nürnberg. 2003–2009 Facharztausbildung für Psychiatrie und Psychotherapie am Universitätsklinikum Erlangen. 2009 Ruf auf eine W2-Professur für Molekulare Psychiatrie an die Medizinische Hochschule Hannover (MHH), dort Geschäftsführender Oberarzt und stellvertretender Klinikdirektor an der Klinik für Psychiatrie, Sozialpsychiatrie und Psychotherapie und Leiter des Labors für Molekulare Neurowissenschaften der MHH.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hillemacher, T., Frieling, H. Alkoholabhängigkeit und Epigenetik. Biospektrum 19, 714–716 (2013). https://doi.org/10.1007/s12268-013-0378-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-013-0378-x

Search

Navigation