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GPCRs — einzelnen Rezeptoren auf der Spur

  • Wissenschaft
  • Schwerpunktthema G-Protein-gekoppelte Rezeptoren
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Abstract

G-protein-coupled receptors have recently been identified at the single molecule level using fluorescent labels attached either to receptors themselves or to their ligands. These studies have revealed a significant heterogeneity of receptors in terms of localization, mobility, and aggregation state (mono-, di- and oligomers). The consequences of this heterogeneity are still largely unknown, but first data suggest that it may result in distinct functions.

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Authors and Affiliations

  1. Rudolf-Virchow-Zentrum und Institut für Pharmakologie und Toxikologie, Universität, Würzburg, Germany

    Martin J. Lohse, Carsten Hoffmann & Davide Calebiro

  2. Institut für Pharmakologie und Toxikologie; Rudolf-Virchow-Zentrum, Universität Würzburg, Versbacher Straße 9, D-97078, Würzburg, Germany

    Martin J. Lohse

Authors
  1. Martin J. Lohse
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  2. Carsten Hoffmann
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  3. Davide Calebiro
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Correspondence to Martin J. Lohse.

Additional information

Martin J. Lohse Medizinstudium an den Universitäten Göttingen, London und Paris. 1981 Promotion. 1988 Habilitation für das Fach Pharmakologie und Toxikologie an der Universität Heidelberg. 1988-1990 Research Assistant und Assistant Professor bei Prof. Dr. R. J. Lefkowitz, Howard Hughes Medical Institute (HHMI), Duke University, Durham, NC, USA. 1990–1993 Gruppenleiter am Max-Planck-Institut für Biochemie, Martinsried. Seit 1993 Professor und Leiter des Instituts für Pharmakologie und Toxikologie der Universität Würzburg. Seit 2001 Leitung des Rudolf-Virchow-Zentrums für experimentelle Bio medizin an der Universität Würzburg.

Carsten Hoffmann Jahrgang 1967. Chemiestudium an der Universität Bremen. 1996 Promotion. 1997–2000 Postdoc, National Institutes of Health, Bethesda, MD, USA. 2000–2003 Postdoc und 2004–2012 Arbeitsgruppenleiter am Institut für Pharmakologie und Toxikologie der Universität Würzburg. 2011 Habilitation für das Fach Pharmakologie und Toxikologie an der Universität Würzburg. Seit 2012 Professor am Bioimaging-Center/Rudolf-Virchow-Zentrum und Institut für Pharmakologie und Toxikologie der Universität Würzburg.

Davide Calebiro Jahrgang 1975, Medizinstudium, PhD (Molekulare Medizin) und Facharztausbildung (Endokrinologie), Universität Mailand, Italien. 2007–2008 Humboldt-Stipendiat Pharmakologie, Universität Würzburg, 2008–2009 Postdoc und Arzt, Experimentelle Endokrinologie, Universität Mailand; seit 2009 wissenschaftlicher Mitarbeiter und AG-Leiter, Bioimaging-Zentrum/Rudolf-Virchow-Zentrum der Universität Würzburg.

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Lohse, M.J., Hoffmann, C. & Calebiro, D. GPCRs — einzelnen Rezeptoren auf der Spur. Biospektrum 19, 600–604 (2013). https://doi.org/10.1007/s12268-013-0358-1

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  • DOI: https://doi.org/10.1007/s12268-013-0358-1

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