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3D-Modellierung der Migration und Invasion von Krebszellen

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Abstract

Progress of cancer research widely depends on methods modelling in vitro the migration of malignant cells and their invasion into hitherto healthy tissues. For this purpose different cancer cell lines are cultivated currently according to the two-dimensional standard model. But there are weighty arguments to switch into the third dimension, more similar to the situation in vivo — a big step to improve the knowledge about metastasic spread and to facilitate design and control of targeted therapies.

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Literatur

  1. Lord CJ, Ashworth A (2010) Biology-driven cancer drug development: back to the future. BMC Biol 8:38

    Article  PubMed  Google Scholar 

  2. Bowen KA, Doan HQ, Zhou BP et al. (2009) PTEN loss induces epithelialmesenchymal transition in human colon cancer cells. Anticancer Res 29:4439–4449

    PubMed  CAS  Google Scholar 

  3. Nyga A, Cheema U, Loizidou M et al. (2011) 3D tumour models: novel in vitro approaches to cancer studies. J Cell Commun Signal 5:239–248

    Article  PubMed  Google Scholar 

  4. Fisher Scientific (2013) Modellierung der Migration und Invasion von Krebszellen durch Anwendung einer neuartigen Technologie für dreidimensionale Zellkulturen, Alvetex®Scaffold, Anwendungsinformation 3, www.de.fishersci.com/images/company/de/Application_Note_3_EU.pdf

    Google Scholar 

  5. LeRoith D, Roberts Jr CT (2003) The insulin-like growth factor system and cancer. Cancer Lett 195:127–137

    Article  PubMed  CAS  Google Scholar 

  6. Kashyap AS, Hollier BG, Manton KJ et al. (2011) Insulin-like growth factor-1: vitronectin complex-induced changes in gene expression effect breast cell survival and migration. Endocrinology 152:1388–1401

    Article  PubMed  CAS  Google Scholar 

  7. De Marco P, Bartella V, Vivacqua A et al. (2013) Insulin-like growth factor-1 regulates GPER expression and function in cancer cells. Oncogene 32:678–88

    Article  PubMed  Google Scholar 

  8. Jones JI, Doerr ME, Clemmons DR (1995) Cell migration: interactions among integrins, IGFs and IGFBPs. Prog Growth Factor Res 6:319–327

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Guido Deußing or Björn Steinhoff.

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Deußing, G., Steinhoff, B. 3D-Modellierung der Migration und Invasion von Krebszellen. Biospektrum 19, 539–541 (2013). https://doi.org/10.1007/s12268-013-0353-6

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  • DOI: https://doi.org/10.1007/s12268-013-0353-6

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