Skip to main content
SpringerLink
Log in

Pilzliche Adhäsine: Klebstoffe für soziales Verhalten und Pathogenität

  • Wissenschaft
  • Zelladhäsion
  • Published:
BIOspektrum Aims and scope

Abstract

Adhesion of cells to biotic and abiotic surfaces is a key for the exchange of genetic material, multicellular development, and colonization of the environment. In fungi, these functions are mediated by fungal adhesins, a family of secreted cell wall glycoproteins that recognize specific carbohydrate or peptide ligands. High-resolution 3D structures of adhesins from apathogenic and pathogenic yeasts now reveal how these proteins confer social interactions and fungal pathogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Borkovich KA, Ebbole DJ (2010) Cellular and molecular biology of filamentous fungi. ASM Press, Washington, DC

    Google Scholar 

  2. Brückner S, Mösch H-U (2012) Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae. FEMS Microbiol Rev 36:25–58

    Article  PubMed  Google Scholar 

  3. Heitman J, Filler SG, Edwards Jr JE et al. (2006) Molecular principles of fungal pathogenesis. ASM Press, New York

    Google Scholar 

  4. Dranginis AM, Rauceo JM, Coronado JE et al. (2007) A biochemical guide to yeast adhesins: glycoproteins for social and antisocial occasions. Microbiol Mol Biol Rev 71:282–294

    Article  PubMed  CAS  Google Scholar 

  5. Linder T, Gustafsson CM (2008) Molecular phylogenetics of ascomycotal adhesins — a novel family of putative cell-surface adhesive proteins in fission yeasts. Fungal Genet Biol 45:485–497

    Article  PubMed  CAS  Google Scholar 

  6. Soares EV (2010) Flocculation in Saccharomyces cerevisiae: a review. J Appl Microbiol 110:1–18

    Article  PubMed  Google Scholar 

  7. Gimeno CJ, Ljungdahl PO, Styles CA et al. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68:1077–1090

    Article  PubMed  CAS  Google Scholar 

  8. Smukalla S, Caldara M, Pochet N et al. (2008) FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast. Cell 135:726–737

    Article  PubMed  CAS  Google Scholar 

  9. Dawkins R (1976) The selfish gene. Oxford University Press, Oxford

    Google Scholar 

  10. Veelders M, Brückner S, Ott D et al. (2010) Structural basis of flocculin-mediated social behavior in yeast. Proc Natl Acad Sci USA 107:22511–22516

    Article  PubMed  CAS  Google Scholar 

  11. Maestre-Reyna M, Diderrich R, Veelders MS et al. (2012) Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia. Proc Natl Acad Sci USA 109:16864–16869

    Article  PubMed  CAS  Google Scholar 

  12. Salgado PS, Yan R, Taylor JD et al. (2011) Structural basis for the broad specificity to host-cell ligands by the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 108:15775–15779

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fachbereich Biologie, Universität Marburg, Marburg, Germany

    Hans-Ulrich Mösch

  2. Fachbereich Biologie, Philipps-Universität Marburg, Karl-von-Frisch-Straß 8, D-35043, Marburg, Germany

    Hans-Ulrich Mösch

Authors
  1. Hans-Ulrich Mösch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hans-Ulrich Mösch.

Additional information

Hans-Ulrich Mösch Biochemiestudium, 1991 Promotion und 1991–1993 Postdoktorand an der ETH Zürich, Schweiz. 1993–1996 Postdoktorand, Whitehead Institute for Biomedical Research, Cambridge und Institute of Technology, Boston, MA, USA. 1996–2003 Gruppenleiter, 2001 Habilitation und 2003–2004 Professor für Genetik, Universität Göttingen. Seit 2004 Professor für Genetik, Universität Marburg.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mösch, HU. Pilzliche Adhäsine: Klebstoffe für soziales Verhalten und Pathogenität. Biospektrum 19, 496–498 (2013). https://doi.org/10.1007/s12268-013-0344-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-013-0344-7

Search

Navigation