Abstract
The degradation of aromatic compounds has long been considered to require dioxygen as co-substrate for oxygenases. However, in anoxic environments anaerobic bacteria employ dearomatizing aromatic ring reductases as key enzymes for the catabolism of aromatic substrates. Surprisingly, there are three totally different biological solutions for the difficult reductive attack on the resonance stabilized aromatic ring system. The dearomatizing reductase classes use FeS-clusters, W-pterins, or flavins as cofactors in their active sites.
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Matthias Boll Jahrgang 1965. Biologiestudium an der Universität Freiburg. 1996 Promotion. 1998–1999 Postdoc am John Innes Center in Norwich, UK. 1999–2006 Arbeitsgruppenleiter am Institut für Biologie an der Universität Freiburg. 2002 Habilitation für das Fach Mikrobiologie. 2006–2012 Professor am Institut für Biochemie, Universität Leipzig. Seit 2012 Professor am Institut für Biologie, Universität Freiburg.
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Boll, M. Aromatenreduktion am negativen Ende der biologischen Redoxskala. Biospektrum 19, 485–488 (2013). https://doi.org/10.1007/s12268-013-0341-x
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DOI: https://doi.org/10.1007/s12268-013-0341-x