Abstract
Aberrant protein aggregation into amyloid fibrils is linked to cell degeneration and the pathogenesis of a number of fatal diseases including Alzheimer’s disease and type 2 diabetes. Here biomolecular recognition principles and peptide-based strategies towards inhibition of protein aggregation and associated cell damage in these two yet incurable amyloid diseases are reviewed.
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Aphrodite Kapurniotu Jahrgang 1961. 1979–1985 Chemiestudium an den Universitäten Athen und Tübingen. 1990 Promotion an der Universität Tübingen. 1990–1992 wissenschaftliche Angestellte an der Universität Tübingen. 1992–1994 Postdoktorandin an der Rutgers University, NJ, USA. 1994–1995 Senior Scientist am Picower Institute for Medical Research, NY, USA. 1994–2007 Gruppenleiterin an der Universität Tübingen und der RWTH Aachen. 2001 Habilitation im Fach Biochemie an der Universität Tübingen. 2006 Ernennung zur apl. Professorin RWTH Aachen. Seit 2007 Professorin für Peptidbiochemie an der TU München.
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Kapurniotu, A. Strategien zur Inhibition der Protein-aggregation bei Amyloidkrankheiten. Biospektrum 18, 734–736 (2012). https://doi.org/10.1007/s12268-012-0255-z
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DOI: https://doi.org/10.1007/s12268-012-0255-z