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Messung molekularer Interaktion mit dynamischen Oberflächensensoren

  • Wissenschaft · Methoden
  • Chip-basierte Methoden
  • Published:
BIOspektrum Aims and scope

Abstract

A novel label-free biosensing technology is introduced which employs a dynamically switchable biosurface. Contrary to conventional biosensors, switchSENSE allows to determine affinity, reaction rates, and molecular size of the target in one analytical run. It constitutes a high-content analytical platform for the discovery of biological drugs and molecular interactions. The determination of KD values and the detection of conformational changes of a Fab-fragment are described here.

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Literatur

  1. Knezevic J, Langer A, Hampel P et al. (2012) Quantitation of affinity, avidity, and binding kinetics of protein analytes with a dynamically switchable biosurface. J Am Chem Soc 134:15225–15228

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Authors and Affiliations

  1. Chemie Department und Walter-Schottky-Institut der TU München und Dynamic Biosensors GMBH, München, Germany

    Ralf Strasser, Dirk Scholl, Paul Hampel, Andreas Langer & Ulrich Rant

  2. Biosensors — Rant lab Chemistry Department, Technische Universität München, Lichtenbergstraße 4, D-85748, Garching, Germany

    Ulrich Rant

Authors
  1. Ralf Strasser
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  2. Dirk Scholl
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  3. Paul Hampel
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  4. Andreas Langer
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  5. Ulrich Rant
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Corresponding author

Correspondence to Ulrich Rant.

Additional information

Ralf Strasser, Dirk Scholl, Paul Hampel, Andreas Langer und Ulrich Rant (v. l. n. r.) Die Dynamic Biosensors GmbH (www.dynamic-biosensors.com) ist ein Spin-off der TU München und beschäftigt sich mit der Entwicklung und Kommerzialisierung der switchSENSE-Technologie. Die Markteinführung ist für Ende 2013 geplant. Zurzeit wird die Technologie im Rahmen eines GO-Bio Förderprojektes des BMBF in der Arbeitsgruppe für Biosensorik am Chemie Department der TU München weiter erforscht.

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Strasser, R., Scholl, D., Hampel, P. et al. Messung molekularer Interaktion mit dynamischen Oberflächensensoren. Biospektrum 18, 724–726 (2012). https://doi.org/10.1007/s12268-012-0252-2

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  • DOI: https://doi.org/10.1007/s12268-012-0252-2

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