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Die Histonvariante CenH3 reguliert die Centromeridentität

Centromerbiologie

  • Wissenschaft · Special: Zellbiologie
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Abstract

The centromere is a specialized chromatin region that functions as foundation for kinetochore formation in mitosis. As a result, it is essential for proper chromosome segregation and the maintenance of genomic integrity. The centromere is defined epigeneti cally by the presence of the histone H3 variant CenH3 that is exclusively found within centromeric chromatin. Additionally, centromeric chromatin displays unique posttranslational modifications that differ from the surrounding heterochromatin.

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Authors and Affiliations

  1. Zmbh, DKFZ-ZMBH Alliance, Universität Heidelberg, Heidelberg, Germany

    Debora Bade & Sylvia Erhardt

  2. Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH) ZMBH-DKFZ Alliance, Universität Heidelberg, Im Neuenheimer Feld 282, D-69120, Heidelberg, Germany

    Sylvia Erhardt

Authors
  1. Debora Bade
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  2. Sylvia Erhardt
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Correspondence to Sylvia Erhardt.

Additional information

Debora Bade Jahrgang 1986. 2005–2010 Biologiestudium an der Universität Heidelberg. Seit 2010 Promotion an der Hartmut Hoffmann-Berling International Graduate School of Molecular and Cellular Biology, Universität Heidelberg.

Sylvia Erhardt Biologiestudium an der Universität Heidelberg. 2003 Promotion an der Universität von Cambridge, UK, danach Postdoc an der Universität von Berkeley, CA, USA. Seit 2008 Nachwuchsgruppenleiterin des Exzellenzclusters CellNetworks im ZMBH an der Universität Heidelberg.

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Bade, D., Erhardt, S. Die Histonvariante CenH3 reguliert die Centromeridentität. Biospektrum 18, 387–389 (2012). https://doi.org/10.1007/s12268-012-0198-4

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  • DOI: https://doi.org/10.1007/s12268-012-0198-4

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