Skip to main content
SpringerLink
Log in

Überlebenskampf zwischen Coxiella burnetii und Wirtszelle

Zelluläre Mikrobiologie

  • Wissenschaft
  • Published:
BIOspektrum Aims and scope

Abstract

Coxiella burnetiiis an obligate intracellular pathogen and the etiological agent of human Q fever. Intracellular survival and inhibition of host cell apoptosis of C. burnetii depends on a functional type IV secretion system (T4SS). We identified several effector proteins of the C. burnetii T4SS and unraveled the function of the T4SS effector protein AnkG. This effector protein inhibits pathogen-induced host cell apoptosis, possibly by binding to the host cell protein p32.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Maurin M, Raoult D (1999) Q Fever. Clin Microbiol Rev 12:518–553

    PubMed  CAS  Google Scholar 

  2. van der Hoek W, Dijkstra F, Schimmer B et al. (2010) Q fever in the Netherlands: an update on the epidemiology and control measures. Euro Surveill 15:19526

    Google Scholar 

  3. Voth D, Heinzen RA (2007) Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii. Cell Microbiol 9:829–840

    Article  PubMed  CAS  Google Scholar 

  4. Pan X, Lührmann A, Satoh A et al. (2008) Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science 320:1651–1654

    Article  PubMed  CAS  Google Scholar 

  5. Lührmann A, Roy CR (2007) Coxiella burnetii inhibits activation of host cell apoptosis through a mechanism that involves preventing cytochrome c release from mitochondria. Infect Immun 75:5282–5289

    Article  PubMed  Google Scholar 

  6. Lührmann A, Nogueira CV, Carey KL et al. (2010) Inhibition of pathogen-induced apoptosis by a Coxiella burnetii type IV effector protein. Proc Natl Acad Sci USA 107:18997–19001

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mikrobiologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany

    Anja Lührmann

  2. Mikrobiologisches Institut, Universitätsklinikum Erlangen, Wasserturmstraße 3-5, D-91054, Erlangen, Germany

    Anja Lührmann

Authors
  1. Anja Lührmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anja Lührmann.

Additional information

Anja Lührmann Biologiestudium an der Universität Leipzig. 1999–2002 Promotion am Mikrobiologie-Lehrstuhl der Universität Würzburg bei Prof. Dr. A. Haas. 2002–2003 Postdoc am Institut für Zellbiologie der Universität Bonn. 2004–2009 Postdoc im Labor von Prof. Dr. C. Roy an der Yale University, New Haven, CT, USA. Seit 2009 Arbeitsgruppenleiterin am Mikrobiologischen Institut — Klinische Mikrobiologie, Immunologie und Hygiene des Universitätsklinikums Erlangen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lührmann, A. Überlebenskampf zwischen Coxiella burnetii und Wirtszelle. Biospektrum 18, 360–362 (2012). https://doi.org/10.1007/s12268-012-0190-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-012-0190-z

Search

Navigation