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Polysialinsäure — ein Zucker reguliert die Hirnentwicklung

  • Wissenschaft
  • Glykobiologie
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Abstract

Modification with polysialic acid controls functions of the neural cell adhesion molecule NCAM during ontogenic processes. This cooperation between a protein and its posttranslational modification provides an outstanding example of how glycans amplify the genomic information and create the functional diversity required to build complex structures like the human brain.

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Literatur

  1. Hildebrandt H, Mühlenhoff M, Gerardy-Schahn R (2010) Polysialylation of NCAM. Adv Exp Med Biol 663:95–109

    Article  PubMed  CAS  Google Scholar 

  2. Hildebrandt H, Mühlenhoff M, Weinhold B et al. (2007) Dissecting polysialic acid and NCAM functions in brain development. J Neurochem 103:56–64

    Article  PubMed  CAS  Google Scholar 

  3. Rutishauser U (2008) Polysialic acid in the plasticity of the developing and adult vertebrate nervous system. Nat Rev Neurosci 9:26–35

    Article  PubMed  CAS  Google Scholar 

  4. Eckhardt M, Mühlenhoff M, Bethe A et al. (1995) Molecular characterization of eukaryotic polysialyltransferase-1. Nature 373:715–718

    Article  PubMed  CAS  Google Scholar 

  5. Galuska SP, Oltmann-Norden I, Geyer H et al. (2006) Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV. J Biol Chem 281:31605–31615

    Article  PubMed  CAS  Google Scholar 

  6. Oltmann-Norden I, Galuska SP, Hildebrandt H et al. (2008) Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development. J Biol Chem 283:1463–1471

    Article  PubMed  CAS  Google Scholar 

  7. Weinhold B, Seidenfaden R, Röckle I et al. (2005) Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule. J Biol Chem 280:42971–42977

    Article  PubMed  CAS  Google Scholar 

  8. Hildebrandt H, Mühlenhoff M, Oltmann-Norden I et al. (2009) Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity. Brain 132:2831–2838

    Article  PubMed  Google Scholar 

  9. Schiff M, Röckle I, Burkhardt H et al. (2011) Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice. J Neurosci 31:1302–1312

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institut für Zelluläre Chemie, Medizinische Hochschule Hannover (MHH), Hannover, Germany

    Herbert Hildebrandt, Martina Mühlenhoff & Rita Gerardy-Schahn

  2. Institut für Zelluläre Chemie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany

    Herbert Hildebrandt & Rita Gerardy-Schahn

Authors
  1. Herbert Hildebrandt
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  2. Martina Mühlenhoff
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  3. Rita Gerardy-Schahn
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Corresponding authors

Correspondence to Herbert Hildebrandt or Rita Gerardy-Schahn.

Additional information

Herbert Hildebrandt Biologiestudium, Universität Tübingen. 1991 Research Fellow, University of Nevada, Reno, USA. 1994 Promotion, FU Berlin. 1994–2005 wissenschaftlicher Mitarbeiter, Assistent und Oberassistent, Universität Hohenheim. 2001 Habilitation in Zoologie. Seit 2006 Professor für Neuroglykobiochemie, Medizinische Hochschule Hannover.

Martina Mühlenhoff Biochemiestudium, Universität Hannover. 1996 Promotion, Universität Hannover. Promotionsarbeit und Postdoc am Institut für Mikrobiologie, Medizinische Hochschule Hannover. Seit 2001 wissenschaftliche Mitarbeiterin am Institut für Zelluläre Chemie, Medizinische Hochschule Hannover.

Rita Gerardy-Schahn Biochemiestudium, Universität Tübingen. 1989 Promotion, Universität Mainz. 1997 Habilitation für Biochemie und Molekularbiologie, Medizinische Hochschule Hannover. 2000–2004 Leiterin der Abteilung für Zelluläre Chemie, Medizinische Hochschule Hannover. Seit 2005 Direktorin des Instituts für Zelluläre Chemie, Medizinische Hochschule Hannover.

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Hildebrandt, H., Mühlenhoff, M. & Gerardy-Schahn, R. Polysialinsäure — ein Zucker reguliert die Hirnentwicklung. Biospektrum 18, 26–29 (2012). https://doi.org/10.1007/s12268-012-0138-3

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  • DOI: https://doi.org/10.1007/s12268-012-0138-3

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