Das Corticotropin-Releasing-Hormon-System und die Angst
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The corticotropin-releasing hormone (CRH) and its receptors coordinate the body’s stress response. A dysregulation of this system plays a role in the development of psychiatric diseases such as depression and anxiety. The selective deletion of CRH receptor type 1 (CRHR1) in neurons of a specific neurotransmitter identity suggests that an imbalance between CRHR1-controlled anxiogenic glutamatergic and anxiolytic dopaminergic circuits might be causally involved in emotional disorders.
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