Skip to main content
Log in

Sehkraft aus der Wüste

  • Wissenschaft · Methoden
  • Gentherapie
  • Published:
BIOspektrum Aims and scope

Zusammenfassung

Die gezielte Expression einer mikrobiellen licht-sensitiven Chloridpumpe in verbliebenen Zellen führt zur funktionellen Reaktivierung der vormals blinden Netzhäuten in der degenerativen Erkrankung Retinitis Pigmentosa und verspricht somit Heilung.

Abstract

The targeted expression of a microbial light-sensitive chloride pump to remaining cells in degenerative retinas led to a functional reactivation of this former blind retinas. This opens a new treatment for the disease retinitis pigmentosa.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. Lancet 368:1795–1809

    Article  PubMed  CAS  Google Scholar 

  2. Wang JS, Kefalov VJ (2011) The cone-specific visual cycle. Prog Retin Eye Res 30:115–128

    Article  PubMed  Google Scholar 

  3. Gollisch T, Meister M (2010) Eye smarter than scientists believed: neural computations in circuits of the retina. Neuron 65:150–164

    Article  PubMed  CAS  Google Scholar 

  4. Zhang F, Wang LP, Brauner M et al. (2007) Multimodal fast optical interrogation of neural circuitry. Nature 446:633–639

    Article  PubMed  CAS  Google Scholar 

  5. Baehr W, Frederick JM (2009) Naturally occurring animal models with outer retina phenotypes. Vision Res 49:2636–2652

    Article  PubMed  Google Scholar 

  6. Busskamp V, Duebel J, Balya D et al. (2010) Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329:413–417

    Article  PubMed  CAS  Google Scholar 

  7. Cepko C (2010) Seeing the light of day. Science 329:403–404

    Article  PubMed  CAS  Google Scholar 

  8. Busskamp V, Roska B (2011) Optogenetic approaches to restoring visual function in retinitis pigmentosa. Curr Opin Neurobiol (im Druck)

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Volker Busskamp.

Additional information

Volker Busskamp Jahrgang 1980. 2001–2005 Studium der Biotechnologie an der TU Braunschweig, Diplomarbeit am Friedrich Miescher Institute for Biomedical Research (FMI) in Basel, Schweiz. 2006 Wissenschaftlicher Mitarbeiter im Laboratory of Virology and Genetics (LVG) der Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne, Schweiz. 2007 Diplom in Biologie an der Universität Genf, Schweiz. 2007–2010 Promotion am Friedrich Miescher Institute bei Dr. Botond Roska. Seit 2011 Postdoc an der Harvard Medical School, Boston, MA, USA.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Busskamp, V. Sehkraft aus der Wüste. Biospektrum 17, 762–764 (2011). https://doi.org/10.1007/s12268-011-0125-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-011-0125-0

Navigation