Zusammenfassung
Die gezielte Expression einer mikrobiellen licht-sensitiven Chloridpumpe in verbliebenen Zellen führt zur funktionellen Reaktivierung der vormals blinden Netzhäuten in der degenerativen Erkrankung Retinitis Pigmentosa und verspricht somit Heilung.
Abstract
The targeted expression of a microbial light-sensitive chloride pump to remaining cells in degenerative retinas led to a functional reactivation of this former blind retinas. This opens a new treatment for the disease retinitis pigmentosa.
Literatur
Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. Lancet 368:1795–1809
Wang JS, Kefalov VJ (2011) The cone-specific visual cycle. Prog Retin Eye Res 30:115–128
Gollisch T, Meister M (2010) Eye smarter than scientists believed: neural computations in circuits of the retina. Neuron 65:150–164
Zhang F, Wang LP, Brauner M et al. (2007) Multimodal fast optical interrogation of neural circuitry. Nature 446:633–639
Baehr W, Frederick JM (2009) Naturally occurring animal models with outer retina phenotypes. Vision Res 49:2636–2652
Busskamp V, Duebel J, Balya D et al. (2010) Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science 329:413–417
Cepko C (2010) Seeing the light of day. Science 329:403–404
Busskamp V, Roska B (2011) Optogenetic approaches to restoring visual function in retinitis pigmentosa. Curr Opin Neurobiol (im Druck)
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Volker Busskamp Jahrgang 1980. 2001–2005 Studium der Biotechnologie an der TU Braunschweig, Diplomarbeit am Friedrich Miescher Institute for Biomedical Research (FMI) in Basel, Schweiz. 2006 Wissenschaftlicher Mitarbeiter im Laboratory of Virology and Genetics (LVG) der Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne, Schweiz. 2007 Diplom in Biologie an der Universität Genf, Schweiz. 2007–2010 Promotion am Friedrich Miescher Institute bei Dr. Botond Roska. Seit 2011 Postdoc an der Harvard Medical School, Boston, MA, USA.
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Busskamp, V. Sehkraft aus der Wüste. Biospektrum 17, 762–764 (2011). https://doi.org/10.1007/s12268-011-0125-0
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DOI: https://doi.org/10.1007/s12268-011-0125-0