Zusammenfassung
Membranständige Purinrezeptoren sind aufgrund der zahlreichen Subtypen und ihrer weiten Verbreitung im Organismus für eine große Bandbreite an medizinischen Indikationen von Interesse.
Abstract
Membrane-localized purine receptors represent a new class of drug targets. Due to the large number of different purine receptor subtypes and their wide distribution in the body they are of interest for a wide range of medical indications.
Literatur
Fredholm BB, IJzerman AP, Jacobson KA et al. (2011) Nomenclature and classification of adenosine receptors - an update. Pharmacol Rev 63:1–34
Brunschweiger A, Müller CE (2006) P2 receptors activated by uracil nucleotides - an update. Curr Med Chem 13:289–312
Xu F, Wu H, Katritch V et al. (2011) Structure of an agonist-bound human A2A adenosine receptor. Science 332:322–327
Müller CE, Jacobson KA (2011) Xanthines as adenosine receptor antagonists. In: Fredholm BB (Hrsg) Methylxanthines. Springer-Verlag, Berlin, Heidelberg, 151–199
Müller CE, Jacobson KA (2011) Recent developments in adenosine receptor ligands and their potential as novel drugs. Biochim Biophys Acta 1808:1290–1308
Hockemeyer J, Burbiel JC, Müller CE (2004) Multigramscale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure - potential drugs for Parkinson’s disease. J Org Chem 69:3308–3318
Armentero MT, Pinna A, Ferré S et al. (2011) Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson’s disease. Pharmacol Ther DOI: 10.1016/j.pharmthera.2011.07.004
Borrmann T, Hinz S, Bertarelli DCG et al. (2009) 1-Alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specifity. J Med Chem 52:3994–4006
Baqi Y, Atzler K, Köse M et al. (2009) High-affinity, nonnucleotide-derived competitive antagonists of platelet P2Y12 receptors. J Med Chem 52:3784–3793
El-Tayeb A, Qi A, Nicholas RA et al. (2011) Structural modifications of UMP, UDP and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem 54:2878–2890
Baqi Y, Hausmann R, Rosefort C et al. (2011) Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. J Med Chem 54:817–830
von Kügelgen I, Schiedel A, Hoffmann K et al. (2008) Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. Mol Pharmacol 73:469–477
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Christa E. Müller 1980–1983 Pharmaziestudium an der Universität Tübingen. 1985 Approbation als Apotheker. 1988 Promotion (Dr. rer. nat.). 1989–1992 Postdoktorandenstipendium der DFG; Forschungsaufenthalte an den National Institutes of Health, Bethesda, MD, USA. 1994 Habilitation im Fach Pharmazeutische Chemie. 1994–1998 Professorin (C3) für Pharmazeutische Chemie an der Universität Würzburg. Seit 1998 Professorin (C4) an der Universität Bonn. Mitgründerin und Sprecherin des Pharma-Zentrums Bonn.
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Müller, C.E. Purinrezeptoren als Zielstrukturen in der Arzneimittelforschung. Biospektrum 17, 645–648 (2011). https://doi.org/10.1007/s12268-011-0103-6
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DOI: https://doi.org/10.1007/s12268-011-0103-6