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Tetrapyrrolbiosynthese in denitrifizierenden Bakterien und Archaea

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  • Molekulare Mikrobiologie
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Zusammenfassung

Die Biosynthese von Häm d 1 in denitrifizierenden Bakterien und Häm in Archaea verläuft ungewübnlicherweise über die methylierte Vorstufe Precorrin-2. Die beteiligten Uroporphyrinogen-III-Methyltransferasen nutzen Arginin als katalytisch aktive Base.

Abstract

The biosynthesis of heme d 1 in denitrifying bacteria and heme in the Archaea proceeds via the methylated intermediate precorrin-2. The involved uroporphyrinogen III methyltransferases utilize arginine as catalytically active base.

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Literatur

  1. Battersby AR (2000) Tetrapyrroles: the pigments of life. Nat Prod Rep 17:507–526

    Article  PubMed  CAS  Google Scholar 

  2. Buchenau B, Kahnt J, Heinemann IU et al. (2006) Heme biosynthesis in Methanosarcina barkeri via a pathway involving two methylation reactions. J Bacteriol 188:8666–8668

    Article  PubMed  CAS  Google Scholar 

  3. Ishida T, Yu L, Akutsu H et al. (1998) A primitive pathway of porphyrin biosynthesis and enzymology in Desulfovibrio vulgaris. Proc Natl Acad Sci USA 95:4853–4858

    Article  PubMed  CAS  Google Scholar 

  4. Stroupe ME, Leech HK, Daniels DS et al. (2003) CysG structure reveals tetrapyrrole-binding features and novel regulation of siroheme biosynthesis. Nat Struct Biol 10:1064–1073

    Article  PubMed  CAS  Google Scholar 

  5. Storbeck S, Walther J, Müller J et al. (2009) The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl-Lmethionine-dependent uroporphyrinogen III methyltransferase required for heme d 1 biosynthesis. FEBS J 276:5973–5982

    Article  PubMed  CAS  Google Scholar 

  6. Storbeck S, Saha S, Krausze J et al. (2011) Crystal structure of the heme d 1 biosynthesis enzyme NirE in complex with its substrate reveals new insights into the catalytic mechanism of S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferases. J Biol Chem 286:26754–26767

    Article  PubMed  CAS  Google Scholar 

  7. Akutsu H, Park J-S, Sano S (1993) L-Methionine methyl is specifically incorporated into the C-2 and C-7 positions of the porphyrin of cytochrome c 3 in a strictly anaerobic bacterium, Desulfovibrio vulgaris. J Am Chem Soc 115:12185–12186

    Article  CAS  Google Scholar 

  8. Cavallaro G, Decaria L, Rosato A (2008) Genome-based analysis of heme biosynthesis and uptake in prokaryotic systems. J Proteome Res 7:4946–4954

    Article  PubMed  CAS  Google Scholar 

  9. Panek H, O’Brian MR (2002) A whole genome view of prokaryotic haem biosynthesis. Microbiology 148:2273–2282

    PubMed  CAS  Google Scholar 

  10. Storbeck S, Rolfes S, Raux-Deery E et al. (2010) A novel pathway for the biosynthesis of heme in Archaea: genomebased bioinformatic predictions and experimental evidence. Archaea 2010:175050

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut für Mikrobiologie, Tu Braunschweig, Braunschweig, Germany

    Sonja Storbeck & Gunhild Layer

  2. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, D-38106, Braunschweig, Germany

    Gunhild Layer

Authors
  1. Sonja Storbeck
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  2. Gunhild Layer
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Corresponding author

Correspondence to Gunhild Layer.

Additional information

Sonja Storbeck 2003–2007 Biologiestudium an der TU Braunschweig. 2007–2011 Doktorarbeit am Institut für Mikrobiologie, TU Braunschweig.

Gunhild Layer 1995–2001 Chemiestudium an der Albert-Ludwigs-Universität Freiburg. 2001–2004 Doktorarbeit am Institut für Mikrobiologie, TU Braunschweig. 2004–2007 Postdoc, Laboratoire de Chimie et Biologie des Métaux, CEA-Grenoble, Frankreich. Seit 2008 Leiterin einer Emmy-Noether-Nachwuchsgruppe, Institut für Mikrobiologie, TU Braunschweig.

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Storbeck, S., Layer, G. Tetrapyrrolbiosynthese in denitrifizierenden Bakterien und Archaea. Biospektrum 17, 637–640 (2011). https://doi.org/10.1007/s12268-011-0102-7

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  • DOI: https://doi.org/10.1007/s12268-011-0102-7

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