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Zellspezifische Aptamere in Diagnostik und Therapie

  • Wissenschaft / Methoden
  • Zell-SELEX
  • Published:
BIOspektrum Aims and scope

Zusammenfassung

Mittels Zell-SELEX lassen sich Aptamere selektieren, die intakte Zellen spezifisch erkennen. Anwendungen liegen in der Identifizierung von Zellpopulationen sowie in der Therapie, da zellspezifische Aptamere regulatorische Effekte auf Zielzellen ausüben oder Wirkstoffe vermitteln können.

Abstract

Cell-SELEX allows the selection of aptamers that specifically recognize live target cells. Applications include isolation and identification of cell populations or their constituents. Furthermore, some of these aptamers show regulatory effects or deliver specific drugs and may therefore be promising therapeutics.

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Author information

Authors and Affiliations

  1. Institut Für Biochemie und Molekularbiologie, Universität Hamburg, Hamburg, Germany

    Cindy Meyer, Ulrich Hahn & Andrea Rentmeister

  2. Department Chemie Institut für Biochemie und Molekularbiologie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146, Hamburg, Germany

    Andrea Rentmeister

Authors
  1. Cindy Meyer
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  2. Ulrich Hahn
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  3. Andrea Rentmeister
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Corresponding author

Correspondence to Andrea Rentmeister.

Additional information

Cindy Meyer Jahrgang 1982. 2001–2006 Biochemiestudium, Universität Leipzig; Diplomarbeit am Institut für Biochemie unter Anleitung von Prof. Dr. Beck-Sickinger. 2006–2009 Promotion am Institut für Biochemie und Molekularbiologie bei Prof. Dr. Hahn, Universität Hamburg. Seit 2010 Postdoctoral Fellow, Institut für Biochemie und Molekularbiologie, Universität Hamburg.

Ulrich Hahn Jahrgang 1950. Studium der Agrarwissenschaften und Biologie (Hauptfach Mikrobiologie), Universität Göttingen. 1980 Promotion am Max-Planck-Institut für experimentelle Medizin, Göttingen. 1982 Akademischer Rat, FU Berlin. 1993 Hochschuldozent, Medizinische Universität zu Lübeck. 1994 Professur für Allgemeine und Mikrobielle Biochemie, Universität Leipzig und 2002 Professur für Biochemie und Molekularbiologie, Universität Hamburg.

Andrea Rentmeister Jahrgang 1977. Chemiestudium in Graz, Österreich und Bonn. 2007 Promotion bei Prof. Dr. Famulok im Bereich Aptamere und Riboswitches, Universität Bonn. 2007–2010 Postdoc bei Prof. Dr. Arnold im Bereich Protein-Engineering am California Institute of Technology, Pasadena, CA, USA. Seit 2010 Junior-Professorin an der Universität Hamburg.

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Meyer, C., Hahn, U. & Rentmeister, A. Zellspezifische Aptamere in Diagnostik und Therapie. Biospektrum 17, 411–413 (2011). https://doi.org/10.1007/s12268-011-0065-8

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  • DOI: https://doi.org/10.1007/s12268-011-0065-8

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