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Überwachung von DNA-Schäden an Kontrollpunkten des Zellzyklus

  • Anwendungen & Produkte
  • Durchflusszytometrie
  • Published:
BIOspektrum Aims and scope

Zusammenfassung

In der vorgestellten Studie werden Arzneimittel-induzierte DNA-Schäden und deren Wirkung im Zellzyklus mittels Durchflusszytometrie bestimmt. Somit kann Durchflusszytometrie eine Hochdurchsatz-Plattform für das Screening niedermolekularer Krebsmedikamente darstellen.

Abstract

In this study, flow cytometry is used to measure drug-induced DNA damage and positioning of this damage within the cell cycle. The data suggest that flow cytometry is a high content platform for screening small molecule cancer drugs.

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Literatur

  1. Kaufmann WK, Paules RS (1996) DNA damage and cell cycle checkpoints. FASEB J 10:238–247

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  2. Zhao H, Traganos F, Darzynkiewicz Z (2010) Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication. Cytometry A 77:285–293

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Author information

Authors and Affiliations

  1. Merck Millipore, Billerica, MA, USA

    Mark Santos, Wenying Zhang, Laura White, Jason Whalley & Matthew Hsu

  2. Millipore Corporation, 28820 Single Oak Drive, Temecula, CA, 92590, USA

    Matthew Hsu

Authors
  1. Mark Santos
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  2. Wenying Zhang
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  3. Laura White
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  4. Jason Whalley
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  5. Matthew Hsu
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Corresponding author

Correspondence to Matthew Hsu.

Additional information

Jason Whalley (links) und Matthew Hsu

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Santos, M., Zhang, W., White, L. et al. Überwachung von DNA-Schäden an Kontrollpunkten des Zellzyklus. Biospektrum 17, 200–202 (2011). https://doi.org/10.1007/s12268-011-0032-4

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  • DOI: https://doi.org/10.1007/s12268-011-0032-4

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