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Modellierung G-Protein-gekoppelter Rezeptoren mit ROSETTA

BIOspektrum volume 17, pages 158–161 (2011)Cite this article

Zusammenfassung

Die Verknüpfung funktioneller und struktureller Informationen über G-Protein-gekoppelte Rezeptoren (GPCRs) ist für das Verständnis dieser komplexen Systeme von Vorteil. Wir beschreiben hier die Modellierung von GPCRs mit der Software ROSETTA, wobei auch flexible Regionen abgebildet werden.

Abstract

Combination of functional and structural information of G-protein coupled receptors (GPCRs) aids the understanding of these complex systems. Here we describe modeling of GPCRs using the ROSETTA software suite, which also covers variable regions like loops or termini.

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Authors and Affiliations

  1. Institut für Biochemie, Universität Leipzig, Leipzig, Germany

    Anette Schreiber

  2. Center for Structural Biology, Vanderbilt University, Nashville, TN, USA

    Jens Meiler

  3. Center for Structural Biology, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN, 37235, USA

    Jens Meiler

Authors
  1. Anette Schreiber
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  2. Jens Meiler
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Corresponding author

Correspondence to Jens Meiler.

Additional information

Anette Schreiber 2005–2010 Biochemiestudium an der Universität Leipzig, Juni-August 2010 Aufenthalt bei Prof. Dr. J. Meiler an der Vanderbilt University, Nashville, TN, USA. Seit 2010 Doktorandin bei Prof. Dr. A. G. Beck-Sickinger an der Universität Leipzig.

Jens Meiler 1993–1998 Chemiestudium an der Universität Leipzig, 1998-2001 Promotion bei Prof. Dr. C. Griesinger, Universität Frankfurt a. M., 2001-2005 Postdoc bei Prof. Dr. D. Baker, University of Washington, Seattle, WA, USA. Seit 2005 Professur für Chemie, Pharmakologie, und Biomedizinische Informatik an der Vanderbilt University, Nashville, TN, USA.

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Schreiber, A., Meiler, J. Modellierung G-Protein-gekoppelter Rezeptoren mit ROSETTA. Biospektrum 17, 158–161 (2011). https://doi.org/10.1007/s12268-011-0021-7

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  • DOI: https://doi.org/10.1007/s12268-011-0021-7