Zusammenfassung
Eine strikte, räumliche und zeitliche Kontrolle der Aktinpolymerisation ist essenziell für eine Vielzahl zellulärer Prozesse. Drosophila-Mutanten haben zu neuen Einblicken in die in vivo-Regulation der Aktindynamik geführt.
Abstract
A tight spatio-temporal coordination of the machineries controlling actin polymerization is essential for a variety of cellular processes. Drosophila mutants have greatly contributed to our understanding of actin dynamics in vivo.
Literatur
Pollard TD, Cooper JA (2009) Actin, a central player in cell shape and movement. Science 326:1208–1212
Liu R, Abreu-Blanco MT, Barry KC et al. (2009) Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development 136:2849–2860
Zallen JA, Cohen Y, Hudson AM et al. (2002) SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila. J Cell Biol 156:689–701
Bogdan S, Stephan R, Lobke C et al. (2005) Abi activates WASP to promote sensory organ development. Nat Cell Biol 7:977–984
Schafer G, Weber S, Holz A et al. (2007) The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila. Dev Biol 304:664–674
Fricke R, Gohl C, Dharmalingam E et al. (2009) Drosophila Cip4/Toca-1 Integrates Membrane Trafficking and Actin Dynamics through WASP and SCAR/WAVE. Curr Biol 19:1429–1437
Bogdan S, Klambt C (2003) Kette regulates actin dynamics and genetically interacts with Wave and Wasp. Development 130:4427–4437
Lebensohn AM, Kirschner MW (2009) Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell 36:512–524
Bogdan S, Grewe O, Strunk M et al. (2004) Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. Development 131:3981–3989
Chotard C, Salecker I (2007) Glial cell development and function in the Drosophila visual system. Neuron Glia Biol 3:17–25
Gohl C, Banovic D, Grevelhoerster A et al. (2010) WAVE can form hetero- and homo-oligomeric complexes at integrin junctions in Drosophila visualized by Bimolecular fluorescence complementation. J Biol Chem 285:40171–40179
Fricke R, Gohl C, Bogdan S (2010) The F-BAR protein family Actin’ on the membrane. Commun Integr Biol 3:89–94
Author information
Authors and Affiliations
Corresponding author
Additional information
Christina Gohl 2001–2006 Biologiestudium an der Universität Münster; dort 2006 Diplomarbeit in Entwicklungs-/Zellbiologie und 2010 Promotion in Entwicklungs-/Zellbiologie.
Thomas Zobel 2003–2009 Biologiestudium an der TU Braunschweig; dort 2009 Diplomarbeit in Entwicklungsgenetik. Seit 2009 Doktorand an der Universität Münster in Entwicklungs-/Zellbiologie.
Sven Bogdan 1991–1996 Biologiestudium an der Universität Bochum; dort 1997 Diplomarbeit in Zellbiochemie. 2000 Promotion in Entwicklungs-/Zellbiologie am Universitätsklinikum Essen. 2000–2005 Wissenschaftlicher Mitarbeiter/Assistent (C1) am Institut für Neuro- und Verhaltensbiologie der WWU Münster; 2006 Unabhängiger Nachwuchsgruppenleiter, Institut für Neuro- und Verhaltensbiologie. 2009 Habilitation (Venia legendi in Zoologie/Neurobiologie).
Rights and permissions
About this article
Cite this article
Gohl, C., Zobel, T. & Bogdan, S. Molekulare Kontrolle der Aktindynamik in vivo bei Drosophila . Biospektrum 17, 28–31 (2011). https://doi.org/10.1007/s12268-011-0005-7
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12268-011-0005-7