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Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway

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Abstract

Myocardial ischemia/reperfusion (I/R) injury after the onset of acute myocardial infarction (AMI) can be life-threatening, and there is no effective strategy for therapeutic intervention. Here, we studied the potential of protectin D1 in protecting from I/R-induced cardiac damages and investigated the underlying mechanisms. An in vivo rat model of I/R after AMI induction was established through the ligation of the left anterior descending (LAD) artery to assess the cardiac functions and evaluate the protective effect of protectin D1. Protectin D1 protected against I/R-induced oxidative stress and inflammation in the rat model, improved the cardiac function, and reduced the infarct size in myocardial tissues. The beneficial effect of protectin D1 was associated with the up-regulation of miRNA-210 and the effects on PI3K/AKT signaling and HIF-1α expression. Together, our data suggest that protectin D1 could serve as a potential cardioprotective agent against I/R-associated cardiac defects.

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Data Availability

The data presented in this study are available upon e-mail request from the corresponding author.

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Funding

This work was supported by the Science and Technology Innovation Foundation of Shenzhen (JCYJ20190806150005453)

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Author notes

  1. Peng Zhang, Jin Wang and Xingsong Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518020, Guangdong, China

    Peng Zhang

  2. Emergency Department, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology, 1017 Dongmen North Road, Luohu District, Shenzhen, 518020, Guangdong, China

    Jin Wang, Li Wang, Shihai Xu & Ping Gong

  3. Department of Anesthesiology, Shouxian Chinese Medicine Hospital, Huainan, 232299, Anhui, China

    Xingsong Wang

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  1. Peng Zhang
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Correspondence to Shihai Xu or Ping Gong.

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This study was approved by the Ethics Committee of Shenzhen People’s Hospital (The Second Clinical Medical College of Jinan University, The First Affiliated Hospital of Southern University of Science and Technology) (LL-KY-2019288).

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Associate Editor Guoping Li oversaw the review of this article

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Zhang, P., Wang, J., Wang, X. et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway. J. of Cardiovasc. Trans. Res. 17, 376–387 (2024). https://doi.org/10.1007/s12265-023-10426-1

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