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Identification of Molecular Markers Predicting the Outcome of Anti-thrombotic Therapy After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome and Atrial fibrillation: Evidence from a Meta-analysis and Experimental Study

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Abstract

Acute coronary syndrome (ACS) and atrial fibrillation (AF) often coexist in clinical practice, and patients with these conditions often have a critical illness with high risk of both ischemia and bleeding. This study aims to report potential molecular markers for predicting the efficacy based on a meta-analysis of microarray data from the GEO database. In 40 patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) treated with PCI, P2RX1’s effects on platelet aggregation, medication resistance, and predictive value were examined. Twenty up-regulated genes in peripheral blood samples of ACS and AF patients were down-regulated after PCI, while 7 down-regulated genes were up-regulated. ACS affected eight potential genes. P2RX1, one of the four LASSO analysis-retrieved disease characteristic genes, accurately predicted AF patients’ thrombosis risk and PCI’s anti-thrombotic impact. Therefore, P2RX1 may be a molecular marker to predict the effect of anti-thrombotic therapy in patients with ACS and AF after PCI.

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Data Availability

The data that supports the findings of this study are available on request from the corresponding author.

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Funding

This study was funded by the Basic Scientific Research of Higher Colleges and Universities in Heilongjiang Province (2022-KYYWF-0791).

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Authors and Affiliations

  1. The Fourth Department of Cardiovascular, The Second Affiliated Hospital of Qiqihar Medical University, No. 37 Zhonghua West Road, Jianhua District, Qiqihar, 161005, Heilongjiang Province, People’s Republic of China

    Jingrui Li, Hongwei Xin, Baihui Zhang, Yuanyuan Ding & Xiaojie Wu

  2. Department of Biochemistry, Qiqihar Medical University, Qiqihar, 161005, People’s Republic of China

    Yanhong Guo

Authors
  1. Jingrui Li
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  2. Hongwei Xin
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  3. Baihui Zhang
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  4. Yanhong Guo
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  5. Yuanyuan Ding
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  6. Xiaojie Wu
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Contributions

Jingrui Li, Hongwei Xin, and Baihui Zhang wrote the paper and conceived and designed the experiments; Yanhong Guo and Yuanyuan Ding analyzed the data; Jingrui Li and Hongwei Xin collected and provided the sample for this study. All authors have read and approved the final submitted manuscript.

Corresponding author

Correspondence to Xiaojie Wu.

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Ethics Approval and Consent to Participate

Our study was approved by the clinical ethics committee of The Second Affiliated Hospital of Qiqihar Medical University, and all patients signed an informed consent form prior to enrolment.

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Not applicable.

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The authors declare no competing interests.

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Associate Editor Craig M. Stolen oversaw the review of this article

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Li, J., Xin, H., Zhang, B. et al. Identification of Molecular Markers Predicting the Outcome of Anti-thrombotic Therapy After Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome and Atrial fibrillation: Evidence from a Meta-analysis and Experimental Study. J. of Cardiovasc. Trans. Res. 16, 1408–1416 (2023). https://doi.org/10.1007/s12265-023-10416-3

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  • DOI: https://doi.org/10.1007/s12265-023-10416-3

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