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Finding New Targets for the Treatment of Heart Failure: Endoplasmic Reticulum Stress and Autophagy

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Abstract

Heart failure is a progressive disease with an annual mortality rate of about 10% and is the end-stage stage of various heart diseases, which places a huge socioeconomic burden on the healthcare system. The development of heart failure has received increasing attention as a potential way to improve the treatment of this disease. Many studies have shown that endoplasmic reticulum stress and autophagy play an important role in the occurrence and development of heart failure. With the in-depth study of endoplasmic reticulum stress and autophagy, both are considered promising targets for pharmacological interventions to treat heart failure, but the mechanism of heart failure between the two is not clear. This review will highlight the effects of endoplasmic reticulum stress, autophagy, and their interactions in the development and development of heart failure, thereby helping to provide direction for the future development of targeted therapies for patients with heart failure.

Clinical Relevance

This study explored the new targets for the treatment of heart failure: endoplasmic reticulum stress and autophagy. Targeted drug therapy for endoplasmic reticulum stress and autophagy is expected to provide a new intervention target for the treatment of heart failure.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 82104721), Tianjin Famous Traditional Chinese Medicine (Junping Zhang) Inheritance Studio Special Funding (Jin Wei Zhong [2020] No. 732), and QI HUANG Scholars (Junping Zhang) Special Funding (National Traditional Chinese Medicine People’s Education Letter [2021] grant number 203).

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  1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300183, China

    Leilei Hu, Dongjie Gao, Hao Lv, Lu Lian, Mingyang Wang, Yunjiao Wang & Junping Zhang

  2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300193, China

    Leilei Hu, Dongjie Gao, Hao Lv, Lu Lian, Mingyang Wang & Yunjiao Wang

  3. Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

    Leilei Hu, Dongjie Gao, Hao Lv, Lu Lian, Mingyang Wang, Yunjiao Wang & Yingyu Xie

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  1. Leilei Hu
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Leilei Hu contributed to proposing ideas; Yingyu Xie and Junping Zhang were responsible for orientation; Leilei Hu and Dongjie Gao were responsible for writing—original draft preparation; Leilei Hu, Dongjie Gao, Mingyang Wang, Hao Lv, and Lu Lian were responsible for content modification; Leilei Hu, Hao Lv, and Yunjiao Wang were responsible for visualization; Junping Zhang was responsible for funding acquisition. All authors have agreed to the publication of this manuscript.

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Correspondence to Yingyu Xie or Junping Zhang.

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Hu, L., Gao, D., Lv, H. et al. Finding New Targets for the Treatment of Heart Failure: Endoplasmic Reticulum Stress and Autophagy. J. of Cardiovasc. Trans. Res. 16, 1349–1356 (2023). https://doi.org/10.1007/s12265-023-10410-9

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